FlyBase Allele Report: Dmel\Dref[GD11784]

General Information

Symbol

Dmel\Dref^GD11784

Species

D. melanogaster

Name

FlyBase ID

FBal0206900

Feature type

allele

Associated gene

Dmel\Dref

Associated Insertion(s)

Carried in Construct

P{GD11784}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11784}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11784

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Dref^GD11784 under the control of Scer\GAL4^Bx-MS1096 results in male flies with severe wing size and patterning defects.

Expression of Dref^GD11784 under the control of Scer\GAL4^Bx-MS1096 results in female flies with severe wing size and patterning defects.

(Schertel et al., 2015)

Expression of Dref^GD11784 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls. No difference is seen in ddaE or vpda neurons.

Expression of Dref^GD11784 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC and v'ada neurons.

(Iyer et al., 2013)

Flies expressing Dref^GD11784 under the control of Scer\GAL4^pnr-MD237 have strong thoracic cleft defects. In addition, the thorax shows loss of macrochaetae. Both of these phenotypes show 100% penetrance.

(Valadez-Graham et al., 2012)

Expression of Dref^GD11784 under the control of Scer\GAL4^Bx-MS1096 results in nearly complete loss of wing tissue.

(Friedman et al., 2011)

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in loss of neuroblasts in the larval brain without any change in size of the remaining neuroblasts.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in mild defects in the shape of neuroblasts in the larval brain.

(Neumüller et al., 2011)

Expression under the control of Scer\GAL4^Mef2.PR results in late pupal lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11784

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dref^GD11784, Scer\GAL4^pnr-MD237 has visible phenotype, suppressible | partially by XNP^RNAi.UAS.Sym, Scer\GAL4^pnr-MD237

(Valadez-Graham et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Dref^GD11784, Scer\GAL4^pnr-MD237 has adult thorax | dorsal phenotype, suppressible by XNP^RNAi.UAS.Sym, Scer\GAL4^pnr-MD237

(Valadez-Graham et al., 2012)

Dref^GD11784, Scer\GAL4^pnr-MD237 has macrochaeta phenotype, suppressible | partially by XNP^RNAi.UAS.Sym, Scer\GAL4^pnr-MD237

(Valadez-Graham et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of XNP^{dsRNA.Scer\UAS.Sym} completely suppresses the thoracic cleft phenotype seen in flies expressing Dref^GD11784 under the control of Scer\GAL4^pnr-MD237 and the penetrance of the loss of thoracic macrochaetae phenotype is reduced to 65%.

(Valadez-Graham et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v22209