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General Information
Symbol
Dmel\Pak3GD8481
Species
D. melanogaster
Name
FlyBase ID
FBal0208004
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Pak3GD8481 under the control of Scer\GAL4ppk.PG results in a reduced dendritic arborization in third instar larval class IV abdominal dorsal multidendritic ddaC neurons, as compared to controls; expression under the control of Scer\GAL4221 has no obvious effect in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons, as compared to controls.

Adults expressing Pak3GD8481 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in flightless flies or defects in wing posture.

Expression under the control of Scer\GAL4Mef2.PR results in grossly normal adult indirect flight muscles.

Expression under the control of Scer\GAL4Mef2.PR results in morphologically wild-type myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the adult indirect flight muscles.

Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 0% or 10-20% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The strong reduction in wing area seen in flies co-expressing all of hpoScer\UAS.cUa, RtGEFScer\UAS.T:Ivir\HA1 and GitScer\UAS.T:Hsap\MYC under the control of Scer\GAL4nub.PU is unaffected if they are also carrying either Pak3GD8481.

The increased number of dendrite terminals in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons expressing knScer\UAS.cHa.T:Ivir\HA1 under the control of Scer\GAL4221 is partially suppressed by co-expressing Pak3GD8481.

Expression of Pak3GD8481 partially suppresses the eye phenotype seen when spasT32 is expressed under the control of Scer\GAL4GMR.PU.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Pak3GD8481
Name Synonyms
Secondary FlyBase IDs
    References (8)