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General Information
Symbol
Dmel\knUAS.cHa.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0296596
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-kn::HA
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of kn cDNA clone RE03728 fused with three copies of Tag:HA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of knScer\UAS.cHa.T:Ivir\HA1 does not significantly affect the compartment organisation of Golgi in larval dendrites.

The expression of knScer\UAS.cHa.T:Ivir\HA1 under the control of Scer\GAL4221 results in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons exhibiting a significant increase in the number of dendrite branch terminals, as compared to controls.

Expression of knScer\UAS.cHa.T:Ivir\HA1 via Scer\GAL42-21 increases the number of higher order branches in class I neurons. knScer\UAS.cHa.T:Ivir\HA1 mis-expression transforms dendritic trees of class I into those of class IV-like in terms of branching complexity and continuous higher-order branch formation, but not in terms of the field size of the avoidance behaviour.

Expression of Scer\GAL4smid-C161>knScer\UAS.cHa.T:Ivir\HA1 causes class II neurons to acquire exuberant branches. They develop far more complicated dendritic arbors than the control branches in terms of both number and total length. On the other hand, Scer\GAL4smid-C161>knScer\UAS.cHa.T:Ivir\HA1 expression greatly decreases the number of terminal structures that distinguish class III. Short straight "spikes" typically cover long branches of the wild-type class III dendrite. In contrast, branches in the mutants are almost naked with only a small number of longer and curved protrusions.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

The increased number of dendrite terminals in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons expressing knScer\UAS.cHa.T:Ivir\HA1 under the control of Scer\GAL4221 is fully suppressed by co-expressing either lolaKK110256 or olf186-FGD3554, is partially suppressed by co-expressing either ImpGD9232, CG14642GD6058 or Pak3GD8481, but is not suppressed by co-expressing Ten-mGD3620.

Co-expression of abScer\UAS.L.cSa reduces the length of 3rd- and higher-order branches compared with expression of Scer\GAL42-21>knScer\UAS.cHa.T:Ivir\HA1 alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
knScer\UAS.cHa.T:Ivir\HA1
knUAS.cHa.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (4)