FlyBase Allele Report: Dmel\Ten-m[GD3620]

The expression of Ten-m^GD3620 under the control of Scer\GAL4^Or47b.7.467 has no significant effect on the pre-synaptic sites of adult olfactory receptor neurons Or47b, as assessed by the number and density of an active zone marker, as compared to controls.

The expression of Ten-m^GD3620 under the control of Scer\GAL4^Mz19 leads to the antennal lobe projection neurons DA1 lPN and VA1d adPN having significant decreases in the number and density of post-synaptic sites, but similar dendrite volume, as compared to controls; this expression also leads to the adult olfactory receptor neurons Or67d, which enervate the adult antennal lobe glomeruli DA1, having a significant decrease in the number of pre-synaptic sites, as assessed by an active zone marker, as compared to controls.

(Mosca and Luo, 2014)

The expression of Ten-m^GD3620 under the control of either Scer\GAL4²²¹, Scer\GAL4^arm.PU, or Scer\GAL4^Ten-m-NP6658, in combination with Dicer-2 for efficient RNAi, results in the secondary dendrite branches of third instar larval class I abdominal dorsal multidendritic ddaE neurons being significantly less directionally biased towards the posterior, as compared to controls; expression under the control of Scer\GAL4²²¹, in combination with Dicer-2 for efficient RNAi, also results in the secondary dendrite branches of third instar larval class I abdominal posterior ventral multidendritic vdap neurons being significantly less directionally biased towards the posterior, as compared to controls.

The expression of Ten-m^GD3620 under the control of Scer\GAL4^ppk.PG, in combination with Dicer-2 for efficient RNAi, results in third instar larval class IV abdominal dorsal multidendritic ddaC neurons showing no significant alteration in dendrite length, number of branch terminals, or spatial disposition of branches within the dendritic tree.

Expression of Ten-m[GD3620] under the control of either Scer\GAL4^ppk.PG or Scer\GAL4^Ten-m-NP6658, in combination with Dicer-2 for efficient RNAi, results in dendrite terminal branches of third instar larval class IV abdominal dorsal multidendritic ddaC neurons exhibiting a significantly less radial directional distribution, as compared to controls; expression under the control of Scer\GAL4^hh-Gal4, in combination with Dicer-2 for efficient RNAi, also results in the dendrite terminal branches of third instar larval class IV abdominal dorsal multidendritic ddaC neurons exhibiting a significantly less radial directional distribution, but only in the dendritic tree region over an Hh-positive epidermal domain, as compared to controls.

(Hattori et al., 2013)

Expression of Ten-m^GD3620 in the olfactory receptor neurons (ORNs) under the control of Scer\GAL4^peb-GAL4 results in mild intermingling of Ncra\QF^Mz19.PH-expressing projection neuron (PN) dendrites and Or47b-expressing ORN axons (these axons and dendrites do not overlap in wild type).

Expression of Ten-m^GD3620 in the PNs (under the control of Scer\GAL4^GH146) does not result in intermingling of Ncra\QF^Mz19.PH-expressing PN dendrites and Or47b-expressing ORN axons.

(Hong et al., 2012)

Expression of Ten-m^GD3620 under the control of Scer\GAL4^Mef2.247 results in a reduction in bouton number at the larval neuromuscular junction.

Expression of Ten-m^GD3620 under the control of Scer\GAL4^Ten-m-NP6658 results in the failure of muscle 3 innervation in 11% of hemisegments. This defect is still seen in the flies are also carrying either Scer\GAL80^elav.PSb or Scer\GAL80^Mhc.PW. The innervation of muscles 2 and 4 is normal in all cases.

(Mosca et al., 2012)

Adults expressing Ten-m^GD3620 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

Adults expressing Ten-m^GD3620 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show no significant change in the kinetics of high temperature (46[o]C) induced paralysis compared to control flies.

(Neely et al., 2010)

External Data

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Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^peb-GAL4, Ten-m^GD3620 has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^peb-GAL4/Ten-a^GD8834

(Hong et al., 2012)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Mz19, Ten-m^GD3620 has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

Enhancer of

Statement

Reference

Ten-m^GD3620/Scer\GAL4^peb-GAL4 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^peb-GAL4, Ten-a^GD8834

(Hong et al., 2012)

NOT Suppressor of

Statement

Reference

Ten-m^GD3620/Scer\GAL4²²¹ is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

Other

Statement

Reference

Scer\GAL4^elav-C155, Ten-a^GD8834, Ten-m^GD3620 has abnormal neuroanatomy phenotype

(Hong et al., 2012)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Mz19, Ten-m^GD3620 has adult antennal lobe projection neuron VA1d adPN phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

Scer\GAL4^Mz19, Ten-m^GD3620 has adult antennal lobe projection neuron DA1 lPN phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

Scer\GAL4^Mz19, Ten-m^GD3620 has synapse | adult stage phenotype, non-enhanceable by Df(1)Ten-a/Df(1)Ten-a

(Mosca and Luo, 2014)

NOT Suppressor of

Statement

Reference

Ten-m^GD3620/Scer\GAL4²²¹ is a non-suppressor of abdominal dorsal multidendritic neuron ddaD | third instar larval stage phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

Ten-m^GD3620/Scer\GAL4²²¹ is a non-suppressor of abdominal dorsal multidendritic neuron ddaE | third instar larval stage phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

Ten-m^GD3620/Scer\GAL4²²¹ is a non-suppressor of dendritic tree | third instar larval stage phenotype of Scer\GAL4²²¹, kn^{UAS.cHa.Tag:HA}

(Hattori et al., 2013)

Other

Statement

Reference

Scer\GAL4^Mef2.247, Ten-a^GD8834, Ten-m^GD3620 has cytoskeleton of presynaptic active zone phenotype

(Mosca et al., 2012)

Scer\GAL4^nrv2.PS, Ten-a^GD8834, Ten-m^GD3620 has cytoskeleton of presynaptic active zone phenotype

(Mosca et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Df(1)Ten-a homozygous mutant adults, also expressing Ten-m^GD3620 under the control of Scer\GAL4^Mz19 present similar decreases in the number and density of post-synaptic sites in antennal lobe projection neurons DA1 lPN and VA1d adPN to adults only expressing Ten-m^GD3620 under the control of Scer\GAL4^Mz19, as compared to controls.

(Mosca and Luo, 2014)

The increased number of dendrite terminals in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons expressing kn^{Scer\UAS.cHa.T:Ivir\HA1} under the control of Scer\GAL4²²¹ is not suppressed by co-expressing Ten-m^GD3620.

(Hattori et al., 2013)

Co-expression of both Ten-a^GD8834 and Ten-m^GD3620 under the control of Scer\GAL4^elav-C155 shifts Or47b-expressing olfactory receptor neuron (ORN) axons to a position between two adjacent Ncra\QF^Mz19.PH-expressing glomeruli (DA1 and VA1d). In addition, Ncra\QF^Mz19.PH-expressing projection neuron (PN) dendrites and Or47b-expressing ORN axons intermingle without a clear border.

Co-expression of both Ten-a^GD8834 and Ten-m^GD3620 under the control of either Scer\GAL4^peb-GAL4 (expressed in the ORNs) or Scer\GAL4^GH146 (expressed in the PNs) results in intermingling of Ncra\QF^Mz19.PH-expressing PN dendrites and Or47b-expressing ORN axons.

(Hong et al., 2012)

Co-expression of Ten-m^GD3620 and Ten-a^GD8834 under the control of Scer\GAL4^Mef2.247 or Scer\GAL4^nrv2.PS results in defects in T-bar ultrastructure, membrane organisation and apposition to contractile tissues.

(Mosca et al., 2012)

Xenogenetic Interactions

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Reference

Complementation and Rescue Data

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Synonyms and Secondary IDs (1)

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Symbol Synonym

Ten-m^GD3620

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References (10)

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