FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Syx5GD1743
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General Information
Symbol
Dmel\Syx5GD1743
Species
D. melanogaster
Name
FlyBase ID
FBal0208682
Feature type
allele
Associated gene
Dmel\Syx5
Associated Insertion(s)
Carried in Construct
P{GD1743}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1743}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1743
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression via "HHLT-gal4" results in loss of progenitor cells in the primary lobes of the larval lymph gland. ("HHLT-gal4" is a combination of Scer\GAL4HCH.Hand and Scer\GAL4Hml.Δ that express in early lymph gland blood cells (hemocytes) and circulating and sessile blood cells, respectively, and incorporates Scer\GAL4Scer\FRT.Rnor\CD2.Act5C to maintain expression in the lymph gland after Scer\GAL4HCH.Hand is down-regulated.)

      (Mondal et al., 2014)

      Adults expressing Syx5GD1743 under the control of the cardioblast-specific Scer\GAL4tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

      (Neely et al., 2010)

      Adults expressing Syx5GD1743 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Expression of Syx5GD1743 in the developing eye using Scer\GAL4GMR.PFa, nervous system using Scer\GAL4elav.PU or midgut using Scer\GAL4mex1.2.1 results in larval or pupal lethality.

      Expression of Syx5GD1743 in a band down the centre of the developing thorax and abdomen under the control of Scer\GAL4pnr-MD237 is normally lethal. However, rare survivors raised at 18[o]C show decreased abdominal pigmentation compared with controls. Expression of Syx5GD1743 using Scer\GAL4pnr-MD237 also leads to the complete loss of the central thorax.

      Flies co-expressing Syx5GD1743 and Syx5Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4pnr-MD237 show decreased pigmentation.

      (Norgate et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early pupal lethality or late pupal lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in lethality before the pupal stage.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Ctr1AGD16726 under the control of Scer\GAL4pnr-MD237 exacerbates the Syx5GD1743-induced hypopigmentation in flies also expressing Syx5Scer\UAS.T:Hsap\MYC.

      Overexpression of Ctr1AScer\UAS.cBa.T:Zzzz\FLAG fails to suppress the hypopigmentation of flies also expressing bot Syx5Scer\UAS.T:Hsap\MYC and Syx5GD1743 under the control of Scer\GAL4pnr-MD237.

      (Norgate et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Syx5GD1743
      Name Synonyms
      Secondary FlyBase IDs
        References (9)