FlyBase Allele Report: Dmel\sfl[GD2336]

General Information

Symbol

Dmel\sfl^GD2336

Species

D. melanogaster

Name

FlyBase ID

FBal0210563

Feature type

allele

Associated gene

Dmel\sfl

Associated Insertion(s)

Carried in Construct

P{GD2336}

Also Known As

UAS-sfl-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2336}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2336

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intellectual disability

CEA

(Reuter et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neonatal diabetes mellitus

modeled by Hsap\INS^C96Y.UAS

(He et al., 2014)

exacerbates mucopolysaccharidosis type IIIA

modeled by Sgsh^GD1578

(Webber et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | adult stage, with Scer\GAL4^elav.PU

(Reuter et al., 2014)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PLu

(Webber et al., 2018)

abnormal memory | adult stage, with Scer\GAL4^elav.PU

(Reuter et al., 2014)

abnormal neuroanatomy | cell non-autonomous | third instar larval stage, with Scer\GAL4^hh-Gal4

(Poe et al., 2017)

decreased occurrence of cell division | adult stage, with Scer\GAL4^NP6267

(Takemura and Nakato, 2017)

partially lethal - majority die, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing sfl^GD2336 under the control of Scer\GAL4^elav.PLu exhibit climbing defects compared to controls.

(Webber et al., 2018)

Expression of sfl^GD2336 in epidermic cells under the control of either Scer\GAL4^A58 or Scer\GAL4^hh-Gal4 results in severe reduction in the overall dendrite or terminal dendrite density as well as terminal dendrite number within the intersegmental area in the adjacent class IV dendritic arborizing neurons in third instar larvae.

(Poe et al., 2017)

Flies expressing sfl^GD2336 under the control of Scer\GAL4^NP6267 (using tub-Gal80[ts] to limit the time of expression to adulthood) display reduced regenerative cell proliferation in the adult posterior midgut upon infection with Pseudomonas entomophila.

(Takemura and Nakato, 2017)

Expression of sfl^GD2336 under the control of Scer\GAL4^GMR.PF has no measurable effect on eye area.

(He et al., 2014)

Expression of sfl^GD2336 under the control of Scer\GAL4^elav.PU (together with UAS-Dicer2 to enhance RNAi efficiency) results in impaired learning and long-term memory, asayed using the courtship behavior experimental paradigm.

(Reuter et al., 2014)

Adults expressing sfl^GD2336 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 50-60% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development