FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CkIIαUAS.Tik
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General Information
Symbol
Dmel\CkIIαUAS.Tik
Species
D. melanogaster
Name
FlyBase ID
FBal0212454
Feature type
allele
Associated gene
Dmel\CkIIα
Associated Insertion(s)
Carried in Construct
P{UAS-CkIIα.Tik}
Also Known As
UAS-Tik, UAS-CkIIαTik
Key Links
Transgenic product class
missense_variant
(Bose et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bose et al., 2006)
Mutagen
in vitro construct
(Bose et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-CkIIα.Tik}
Cytology
Description

Amino acid replacement: M161K.

(Bose et al., 2006)

UAS regulatory sequences drive expression of a mutated form of CkIIα, that carries the same mutations as the CkIIαTik allele.

(Bose et al., 2006)

Amino acid replacement: E165D.

(Bose et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
CkIIα
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CkIIαScer\UAS.Tik under the control of Scer\GAL4sca-537.4 does not perturb the eye and leads to subtle, yet reproducible, defects in interommatidial bristle patterning.

      Expression of CkIIαScer\UAS.Tik under the control of Scer\GAL4ey.3.5.Exel results in a rough eye and defective interommatidial bristle patterning when flies are raised at 29oC, but not when flies are raised at 24oC.

      Expression of CkIIαScer\UAS.Tik under the control of Scer\GAL4sca-537.4 leads to the formation of extra bristles on the scutellum.

      (Bose et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The loss of the scutellar macrochaetes and interommatidial bristles resulting from expression of E(spl)m8-HLHScer\UAS.cUa with Scer\GAL4sca-537.4 is suppressed by co-expression of CkIIαScer\UAS.Tik.

      Expression of CkIIαScer\UAS.Tik mediated by Scer\GAL4h-H10 suppresses the Nspl-1/Y rough and reduced eye.

      (Kahali et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CkIIαScer\UAS.Tik
      CkIIαUAS.Tik
      Name Synonyms
      Secondary FlyBase IDs
        References (6)