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General Information
Symbol
Dmel\AMPKαD1
Species
D. melanogaster
Name
FlyBase ID
FBal0213117
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the insertion in SNF1AG505, resulting in a deletion of SNF1A sequences.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutants die before the mid-pupal stage.

Embryos lacking both maternal and zygotic SNF1A+ function (derived from homozygous female germline clones) do not develop into larvae. The mutant embryos have severely deformed cuticle structures and ventral denticle belts are missing. Ultrastructurally, the surface of the embryo is roughened and the columnar structure of the epidermis is disorganised. Some cells contain abnormally enlarged nuclei in these embryos, and approximately 30% of mitotic cells are polyploid.

Homozygous larvae have a high fraction of mitotic brain neuroblasts that show extreme polyploidy.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

The cuticle defects seen in mutant embryos derived from SNF1AD1 homozygous female germline clones are partially suppressed by sqhE20.E21; the fraction of embryos that form cuticle is increased from approximately 10% to approximately 30%.

The fraction of SNF1AD1 mitotic larval brain neuroblasts that show extreme polyploidy is decreased if the larvae are also mutant for sqhE20.E21.

The fraction of SNF1AD1 mitotic larval brain neuroblasts that show extreme polyploidy is not changed if the larvae are also co-expressing lkb1Scer\UAS.cLa under the control of Scer\GAL4hs.PB.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
AMPKαD1
SNF1AD1
Name Synonyms
Secondary FlyBase IDs
    References (1)