FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PDZ-GEF5
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General Information
Symbol
Dmel\PDZ-GEF5
Species
D. melanogaster
Name
FlyBase ID
FBal0216663
Feature type
allele
Associated gene
Dmel\PDZ-GEF
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Singh et al., 2006, Wang et al., 2006)
Mutagen
P-element activity
(Wang et al., 2006)
Progenitor genotype
PDZ-GEF3
(Wang et al., 2006)
Cytology
Description

Imprecise excision of P{lacW}Gef263 has left some residual P{lacW} sequence (~1.1Kb).

(Wang et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye and wing phenotypes (small rough eyes, abnormal wings) and some degree of lethality are seen in various PDZ-GEF allelic combinations, with their relative strength in the following order: PDZ-GEF4/PDZ-GEF6 = PDZ-GEF4/PDZ-GEF5 > PDZ-GEF3/PDZ-GEF4 > PDZ-GEFk13720/PDZ-GEF3 = PDZ-GEFk13720/PDZ-GEF4 > PDZ-GEFEP388/PDZ-GEF3 > PDZ-GEFk13720/PDZ-GEFk13720 > PDZ-GEFk13720/PDZ-GEFEP388 > PDZ-GEFEP388/PDZ-GEFEP388.

      Many mutant females have three spermathecae instead of two, with different allelic combinations having different percentages of females with three spermathecae: PDZ-GEF3/PDZ-GEF3 22%, PDZ-GEF3/PDZ-GEF4 30%, PDZ-GEF4/PDZ-GEF5 59%, PDZ-GEF4/PDZ-GEF6 62%, PDZ-GEFk13720/PDZ-GEF4 % (all PDZ-GEFk13720/PDZ-GEF4, PDZ-GEFk13720/PDZ-GEF3 or PDZ-GEFEP388/PDZ-GEF3 females have two spermathecae).

      (Singh et al., 2006)

      The number of male germline stem cells is dramatically reduced in the testes of Gef265/Gef264 animals compared to wild-type. In these testes, the secondary spermatogonia, with branched fusomes, move to the tip.

      (Wang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      PDZ-GEF5/PDZ-GEF4 is partially rescued by PDZ-GEF+t11.6

      (Singh et al., 2006)
      Comments

      PDZ-GEF+t11.6 rescues eye and wing phenotypes of PDZ-GEF4/PDZ-GEF5 flies. PDZ-GEF+t11.6 partially rescues the supernumerary spermathecae phenotype in PDZ-GEF4/PDZ-GEF5 flies.

      (Singh et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gef265
      (Singh et al., 2006)
      PDZ-GEF5
      Name Synonyms
      Secondary FlyBase IDs
        References (2)