FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PDZ-GEF+t11.6
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General Information
Symbol
Dmel\PDZ-GEF+t11.6
Species
D. melanogaster
Name
FlyBase ID
FBal0216666
Feature type
allele
Associated gene
Dmel\PDZ-GEF
Associated Insertion(s)
Carried in Construct
P{PDZ-GEF+}
Also Known As
p{Gef26+}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Wang et al., 2006)
wild_type
(Wang et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Wang et al., 2006)
wild_type
(Wang et al., 2006)
Mutagen
in vitro construct
(Wang et al., 2006)
Progenitor genotype
Carried in construct
P{PDZ-GEF+}
Cytology
Description

11628bp genomic fragment which includes the complete PDZ-GEF gene and the C-terminal portion of Ddr. (Sequence coordinates of the fragment are -2331bp to +9297bp relative to the site of the P{EP}PDZ-GEFEP388 insertion).

(Singh et al., 2006)

An 11.6kb genomic fragment including the entire Gef26 coding region, over 2kb of upstream sequence and over 1 kb of downstream sequence.

(Wang et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
PDZ-GEF
Encoded product / tool
PDZ-GEF
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2L:6,321,329..6,332,957 [+]
Comment:

Rescue fragment reported to be -2331bp to +9297bp relative to the site of the P{EP}PDZ-GEFEP388 insertion. P{EP}PDZ-GEFEP388 is 762 bp upstream of P{lacW}PDZ-GEF3 according to this paper or 2L:6323797 .

(Singh et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      PDZ-GEF+t11.6 rescues PDZ-GEF3/PDZ-GEF4

      (Singh et al., 2006)
      Partially rescues

      PDZ-GEF+t11.6 partially rescues PDZ-GEF5/PDZ-GEF4

      (Singh et al., 2006)
      Comments

      PDZ-GEF+t11.6 rescues eye and wing phenotypes of PDZ-GEF3/PDZ-GEF4, PDZ-GEF4/PDZ-GEF5 or PDZ-GEF4/PDZ-GEF6 flies. PDZ-GEF+t11.6 partially rescues the supernumerary spermathecae phenotype in PDZ-GEF4/PDZ-GEF5 flies.

      (Singh et al., 2006)

      Germline stem cell loss in the testes of Gef264/Gef266 animals is rescued by Gef26+t11.6.

      (Wang et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gef26+t11.6
      PDZ-GEF+t11.6
      Name Synonyms
      Secondary FlyBase IDs
        References (2)