FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\painNP7022
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General Information
Symbol
Dmel\painNP7022
Species
D. melanogaster
Name
FlyBase ID
FBal0228337
Feature type
allele
Associated gene
Dmel\pain
Associated Insertion(s)
P{GawB}painNP7022
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}painNP7022
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant animals with a painGAL4/painNP7022 genotype show pronounced thermal nociception and mechanical nociception defective phenotype. In mechanical niciception test, painGAL4/painNP7022 trans-heterozygotes respond approximately 40% of the time to a 50mN Von-Frey fiber (compared to 70% in wild-type).

        (Hwang et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        painNP7022/painGAL4 is rescued by Scer\GAL4NP7022/painp103.UAS.Venus/Scer\GAL4pain-GAL4

        (Hwang et al., 2012)

        painNP7022/painGAL4 is rescued by Scer\GAL4NP7022/painp60.UAS.Venus/Scer\GAL4pain-GAL4

        (Hwang et al., 2012)
        Not rescued by

        painNP7022/painGAL4 is not rescued by Scer\GAL4NP7022/painp103.UAS.Venus/Scer\GAL4pain-GAL4

        (Hwang et al., 2012)

        painNP7022/painGAL4 is not rescued by Scer\GAL4NP7022/painp60.UAS.Venus/Scer\GAL4pain-GAL4

        (Hwang et al., 2012)
        Comments

        Expression of painp103.Scer\UAS.T:Avic\GFP-YFP.Venus under the control of Scer\GAL4pain-GAL4 and Scer\GAL4NP7022 results in a nearly complete rescue of nociception responses to a 46[o]C thermal stimulus in painGAL4/painNP7022 trans-heterozygotes. However, expression of painp103.Scer\UAS.T:Avic\GFP-YFP.Venus does not rescue mechanical nociception.

        Expression of painp60.Scer\UAS.T:Avic\GFP-YFP.Venus under the control of Scer\GAL4pain-GAL4 and Scer\GAL4NP7022 does not rescue nociception responses to a 46[o]C thermal stimulus in painGAL4/painNP7022 trans-heterozygotes but does improve the mechanical nociception responses of the mutant animals, such that they are no longer different from wild-type.

        (Hwang et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        painNP7022
        Name Synonyms
        Secondary FlyBase IDs
          References (2)