FlyBase Allele Report: Dmel\RIOK1[KK100810]

General Information

Symbol

Dmel\RIOK1^KK100810

Species

D. melanogaster

Name

FlyBase ID

FBal0230930

Feature type

allele

Associated gene

Dmel\RIOK1

Associated Insertion(s)

Carried in Construct

P{KK100810}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100810}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100810

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates brain glioma

modeled by btl::Egfr^λ.UAS, Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

(Read et al., 2013)

modeled by Hsap\EGFR^Δ.UAS

(Read et al., 2013)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^50.UAS.EGFP

(Lee et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

decreased body size | pupal stage, with Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^Ilp2.PR-mediated expression results in a significant reduction in pupal volume and the body weight of emerging adults compared to controls.

(Hasygar and Hietakangas, 2014)

Expression of RIOK1^KK100810 under the control of Scer\GAL4^repo.PU has no effect on third instar larval brain size.

(Read et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

RIOK1^KK100810, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^JF02513, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK1^KK100810, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^KK113065, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Suppressor of

Statement

Reference

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2013)

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2013)

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU

(Read et al., 2013)

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU

(Read et al., 2013)

Other

Statement

Reference

Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, RIOK1^KK100810, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS has abnormal neuroanatomy | third instar larval stage phenotype

(Read et al., 2013)

Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, RIOK1^KK100810, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS has hypoplasia | third instar larval stage phenotype

(Read et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of glial cell | increased number | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2013)

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2013)

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of glial cell | increased number | third instar larval stage phenotype of Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU

(Read et al., 2013)

RIOK1^KK100810, Scer\GAL4^repo.PU is a suppressor of larval brain | third instar larval stage phenotype of Hsap\EGFR^Δ.UAS, Scer\GAL4^repo.PU

(Read et al., 2013)

Other

Statement

Reference

Additional Comments

Genetic Interactions

Statement

Reference

Expression of RIOK1^KK100810 suppresses the increase in brain size and glial overgrowth seen when btl::Egfr^{Scer\UAS.T:λ\cI-DD} and Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} are co-expressed under the control of Scer\GAL4^repo.PU. There are few excess glia and remaining glial cells show abnormal development. The resulting brains are smaller in size than controls, due to a reduction in both glial and neuronal cells.

(Read et al., 2013)

Xenogenetic Interactions

Statement

Reference

Expression of RIOK1^KK100810 suppresses the brain enlargement and glial overgrowth seen when Hsap\EGFR^Δ.Scer\UAS is expressed under the control of Scer\GAL4^repo.PU. There are few excess glia and remaining glial cells show abnormal development.

(Read et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105395

P{KK100810}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG11660^KK100810

RIOK1^KK100810

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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