FlyBase Allele Report: Dmel\p53[JF02513]

General Information

Symbol

Dmel\p53^JF02513

Species

D. melanogaster

Name

FlyBase ID

FBal0242195

Feature type

allele

Associated gene

Dmel\p53

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02513}

Key Links

Genomic Maps

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Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - RNAi

(Perkins et al., 2009)

in vitro construct - regulatory fusion

(Perkins et al., 2009)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{TRiP.JF02513}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

p53

Also carries

loxP

recombinase target site

Associated Sequence Features

dsRNA-JF02513

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alexander disease

modeled by Hsap\GFAP^R79H.UAS

(Wang et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of p53^JF02513 under the control of Scer\GAL4^repo does not significantly affect number of adult brain glial cells at 7 days post-eclosion.

(Foo, 2017)

Scer\GAL4^Ilp2.PR-mediated expression does not result in a significant reduction in pupal volume compared to controls.

(Hasygar and Hietakangas, 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

p53^JF02513, Scer\GAL4^ey.PU is a suppressor of abnormal size | adult stage phenotype of HUWE1^GD13830, Scer\GAL4^ey.PU

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^ey.PU is a suppressor of visible | adult stage phenotype of HUWE1^GD13830, Scer\GAL4^ey.PU

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^ey.PU is a suppressor of abnormal size | larval stage phenotype of HUWE1^GD13830, Scer\GAL4^ey.PU

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^ptc-559.1 is a suppressor of abnormal size | larval stage phenotype of HUWE1^GD13830, Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^repo.PU is a suppressor of increased cell death | adult stage phenotype of Hsap\GFAP^R79H.UAS, Scer\GAL4^repo.PU

(Wang et al., 2015)

p53^JF02513, Scer\GAL4^repo.PU is a suppressor of bang sensitive phenotype of Hsap\GFAP^R79H.UAS, Scer\GAL4^repo.PU

(Wang et al., 2015)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK1^KK100810, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK1^GD8541, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^KK101850, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

NOT Suppressor of

Statement

Reference

p53^JF02513, Scer\GAL4^repo.PU is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU

(Wang et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

p53^JF02513, Scer\GAL4^ptc-559.1 is a suppressor of embryonic/larval salivary gland | larval stage phenotype of HUWE1^GD13830, Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^ptc-559.1 is a suppressor of nucleus | larval stage phenotype of HUWE1^GD13830, Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^ey.PU is a suppressor of eye phenotype of HUWE1^GD13830, Scer\GAL4^ey.PU

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^ey.PU is a suppressor of eye disc phenotype of HUWE1^GD13830, Scer\GAL4^ey.PU

(Yanku et al., 2018)

p53^JF02513, Scer\GAL4^repo.PU is a suppressor of adult brain phenotype of Hsap\GFAP^R79H.UAS, Scer\GAL4^repo.PU

(Wang et al., 2015)

NOT Suppressor of

Statement

Reference

p53^JF02513, Scer\GAL4^repo.PU is a non-suppressor of adult brain phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU

(Wang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of p53^JF02513 does not significantly alter neurodegeneration in flies with expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^repo.PU. Co-expression of p53^JF02513 significantly suppresses cell death and seizure frequency in flies with expression of Hsap\GFAP^{R79H.Scer\UAS} driven by Scer\GAL4^repo.PU.

(Wang et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29351

y¹ v¹; P{TRiP.JF02513}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

p53^JF02513

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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