FlyBase Allele Report: Dmel\pHCl-2[KK106835]

General Information

Symbol

Dmel\pHCl-2^KK106835

Species

D. melanogaster

Name

FlyBase ID

FBal0234522

Feature type

allele

Associated gene

Dmel\pHCl-2

Associated Insertion(s)

Carried in Construct

P{KK106835}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK106835}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK106835

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^mex1.2.1

(Redhai et al., 2020)

abnormal developmental rate, with Scer\GAL4^pHCl-2.PR

(Redhai et al., 2020)

decreased rate of feeding behavior | larval stage, with Scer\GAL4^pHCl-2.PR

(Redhai et al., 2020)

partially lethal, with Scer\GAL4^mex1.2.1

(Redhai et al., 2020)

some die during larval stage, with Scer\GAL4^mex1.2.1

(Redhai et al., 2020)

Phenotype Manifest In

embryonic/larval midgut | larval stage, with Scer\GAL4^pHCl-2.PR

(Redhai et al., 2020)

Detailed Description

Statement

Reference

Expression of pHCl-2^KK106835 under the control of Scer\GAL4^mex1.2.1 leads to a developmental delay. This delay is exacerbated, and is accompanied by significantly reduced larval viability when animals raised under low yeast conditions.

Constitutive or post-embryonic expression of pHCl-2^KK106835 under the control of Scer\GAL4^pHCl-2.PR (in combination with tub-Gal80[ts]) leads to a developmental delay in animals raised under low yeast conditions.

Expression of pHCl-2^KK106835 under the control of Scer\GAL4^pHCl-2.PR leads to reduced food intake and luminal acidity in the copper cell region of midgut in larvae raised under low yeast conditions.

(Redhai et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^pHCl-2.PR, pHCl-2^KK106835 has abnormal developmental rate phenotype, enhanceable by mTor^HMS01114/Scer\GAL4^pHCl-2.PR

(Redhai et al., 2020)

Suppressed by

Statement

Reference

Scer\GAL4^pHCl-2.PR, pHCl-2^KK106835 has abnormal developmental rate phenotype, suppressible by S6k^STDETE.UAS, Scer\GAL4^pHCl-2.PR

(Redhai et al., 2020)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108337

P{KK106835}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG11340^KK106835

pHCl-2^KK106835

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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