FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\AkhKK113271
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General Information
Symbol
Dmel\AkhKK113271
Species
D. melanogaster
Name
FlyBase ID
FBal0238685
Feature type
allele
Associated gene
Dmel\Akh
Associated Insertion(s)
Carried in Construct
P{KK113271}
Also Known As
UAS-Akh-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK113271}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK113271
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adulthood-only expression of AkhKK113271 under the control of Scer\GAL4Akh.PL (together with Gal80[ts] for the temporal control of expression), leads to increased resistance (survival) to starvation.

      (Koyama et al., 2021)

      Knockdown of AkhKK113271 driven by Scer\GAL4Akh.PL significantly increases survival under starvation conditions, compared to controls.

      (Hentze et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of AkhKK113271 and AstA-R2GD339 driven by Scer\GAL4Akh.PL significantly enhances starvation resistance (compared to starvation resistance in either Scer\GAL4Akh.PL>AkhKK113271 or Scer\GAL4Akh.PL>AstA-R2GD339 alone).

      (Hentze et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AkhKK113271
      AkhRNAi
      (Koyama et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)