FlyBase Allele Report: Dmel\tau[HM05101]

General Information

Symbol

Dmel\tau^HM05101

Species

D. melanogaster

Name

FlyBase ID

FBal0240231

Feature type

allele

Associated gene

Dmel\tau

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05101}

Also Known As

tau RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05101}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05101

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

exacerbates amyotrophic lateral sclerosis type 21

modeled by Hsap\MATR3^{S85C.UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

modeled by Hsap\MATR3^{UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

modeled by Hsap\MATR3^{F115C.UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

modeled by Hsap\MATR3^{T622A.UAS.cZa.Tag:FLAG}

(Zhao et al., 2020)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Wang et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | progressive, with Scer\GAL4^GMR.PU

(Bolkan and Kretzschmar, 2014)

decreased rate of adult locomotory behavior, with Scer\GAL4^elav.PU

(Goodman et al., 2024)

decreased rate of adult locomotory behavior, with Scer\GAL4^GS.repo

(Goodman et al., 2024)

increased sleep | adult stage, with Scer\GAL4^GS.repo

(Goodman et al., 2024)

short lived, with Scer\GAL4^GS.repo

(Goodman et al., 2024)

Phenotype Manifest In

adult brain, with Scer\GAL4^GS.repo

(Goodman et al., 2024)

lipid droplet | adult stage | decreased number, with Scer\GAL4^GS.repo

(Goodman et al., 2024)

retina | progressive, with Scer\GAL4^GMR.PU

(Bolkan and Kretzschmar, 2014)

Detailed Description

Statement

Reference

Expression of tau^HM05101 under the control of Scer\GAL4^ppk.PU, in combination with a Dicer-2 transgene to enhance RNAi efficiency, does not impair pruning of ddaC dendrites by 16 h after puparium formation (APF), compared to controls.

(Wang et al., 2019)

Expression of tau^HM05101 under the control of Scer\GAL4^ppk.PG does not induce precocious dendrite pruning in class IV dendritic arborizing neurons at the pupal stage.

(Herzmann et al., 2017)

Flies expressing tau^HM05101 under the control of Scer\GAL4^GMR.PU show a rapid progressive pattern of retinal degeneration, that starts in the proximal part of the retina and becomes progressively worse when the flies are aged for four weeks.

(Bolkan and Kretzschmar, 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

tau^HM05101, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

NOT Enhancer of

Statement

Reference

tau^HM05101, Scer\GAL4^ppk.PU is a non-enhancer of abnormal neuroanatomy | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

tau^HM05101, Scer\GAL4^ppk.PU is a non-enhancer of abnormal cell shape | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

Suppressor of

Statement

Reference

tau^HM05101/Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^GMR.PF, milt^GD8116

(Iijima-Ando et al., 2012)

NOT Suppressor of

Statement

Reference

tau^HM05101, Scer\GAL4^ppk.PU is a non-suppressor of abnormal neuroanatomy | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

tau^HM05101, Scer\GAL4^ppk.PU is a non-suppressor of abnormal cell shape | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

Other

Statement

Reference

ND-42^ninaE.GD6220, Scer\GAL4^54C, tau^HM05101 has abnormal cell size | adult stage phenotype

(Goodman et al., 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

tau^HM05101, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

NOT Enhancer of

Statement

Reference

tau^HM05101, Scer\GAL4^ppk.PU is a non-enhancer of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

tau^HM05101, Scer\GAL4^ppk.PU is a non-enhancer of dendrite | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

Suppressor of

Statement

Reference

tau^HM05101/Scer\GAL4^54C is a suppressor of lipid droplet | increased number | adult stage phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

tau^HM05101/Scer\GAL4^54C is a suppressor of ommatidium | adult stage phenotype of ND-42^ninaE.GD6220

(Goodman et al., 2024)

tau^HM05101/Scer\GAL4^GMR.PF is a suppressor of lamina phenotype of Scer\GAL4^GMR.PF, milt^GD8116

(Iijima-Ando et al., 2012)

NOT Suppressor of

Statement

Reference

tau^HM05101, Scer\GAL4^ppk.PU is a non-suppressor of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

tau^HM05101, Scer\GAL4^ppk.PU is a non-suppressor of dendrite | pupal stage phenotype of Patronin^KK100898, Scer\GAL4^ppk.PU

(Wang et al., 2019)

Other

Statement

Reference

ND-42^ninaE.GD6220, Scer\GAL4^54C, tau^HM05101 has vacuole | adult stage phenotype

(Goodman et al., 2024)

ND-42^ninaE.GD6220, Scer\GAL4^54C, tau^HM05101 has adult glial cell phenotype

(Goodman et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of tau^HM05101 suppresses the neurodegeneration seen in the lamina of 30 day old flies when milt^GD8116 is expressed under the control of Scer\GAL4^GMR.PF.

(Iijima-Ando et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28891

y¹ v¹; P{TRiP.HM05101}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tau^HM05101

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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