FlyBase Allele Report: Dmel\Rac1[JF02813]

General Information

Symbol

Dmel\Rac1^JF02813

Species

D. melanogaster

Name

FlyBase ID

FBal0240325

Feature type

allele

Associated gene

Dmel\Rac1

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02813}

Also Known As

UAS-Rac1-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02813}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02813

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of kidney disease

CEA

(Zhang et al., 2013)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Kikuchi et al., 2020)

ameliorates neurodegenerative disease

modeled by ifc^KO

(Tzou et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval pericardial cell, with Scer\GAL4^Ugt36A1.PK

(Zhang et al., 2013)

Detailed Description

Statement

Reference

Scer\GAL4^Dot.PK-mediated expression of Rac1^JF02813 reduces the normal accumulation of ANF-RFP (expressed via Rnor\ANF^{Mhc.T:Disc\RFP}) in pericardial nephrocytes.

(Zhang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rac1^JF02813/Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813, Scer\GAL4^Mz19 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^Mz19, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813/Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04 is a suppressor of abnormal neuroanatomy | somatic clone | P-stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Rac1^JF02813, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Rac1^JF02813/Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04 is a suppressor of filamentous actin | somatic clone phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813/Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04 is a suppressor of neuron projection | adult stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813, Scer\GAL4^Mz19 is a suppressor of neuron projection | adult stage phenotype of Scer\GAL4^Mz19, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813/Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04 is a suppressor of adult antennal lobe | somatic clone | P-stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813/Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04 is a suppressor of adult antennal lobe phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813, Scer\GAL4^Mz19 is a suppressor of adult antennal lobe phenotype of Scer\GAL4^Mz19, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813/Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04 is a suppressor of adult antennal olfactory receptor neuron | somatic clone | P-stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Rac1^JF02813, Scer\GAL4^repo.PU is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Rac1^JF02813, Scer\GAL4^repo.PU is a suppressor of larval brain neuropil glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28985

y¹ v¹; P{TRiP.JF02813}attP2 e^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rac1^JF02813

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections