FlyBase Allele Report: Hsap\APLP1[UAS.cMa]

General Information

Symbol

Hsap\APLP1^UAS.cMa

Species

H. sapiens

Name

FlyBase ID

FBal0241989

Feature type

allele

Associated gene

Hsap\APLP1

Associated Insertion(s)

Carried in Construct

P{UAS-APLP1.M}

Key Links

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Merdes et al., 2004)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-APLP1.M}

Cytology

Nature of the lesion

Statement

Reference

UAS sequences drive expression of Hsap\APLP1.

(Merdes et al., 2004)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\APLP1

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | third instar larval stage, with Scer\GAL4^dpp.PU

(Wang et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^elav.PU

(Wang et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^en.PU

(Wang et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^GMR.PU

(Wang et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^pnr-MD237

(Wang et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

visible, with Scer\GAL4^dpp.PU

(Wang et al., 2015)

visible, with Scer\GAL4^en.PU

(Wang et al., 2015)

visible, with Scer\GAL4^pnr-MD237

(Wang et al., 2015)

visible, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

visible, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

Phenotype Manifest In

anterior crossvein | adult stage, with Scer\GAL4^dpp.PU

(Wang et al., 2015)

anterior crossvein | adult stage, with Scer\GAL4^en.PU

(Wang et al., 2015)

anterior crossvein | adult stage, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^dpp.PU

(Wang et al., 2015)

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

(Wang et al., 2015)

eye disc | third instar larval stage, with Scer\GAL4^GMR.PU

(Wang et al., 2015)

larval ventral nerve cord | third instar larval stage, with Scer\GAL4^elav.PU

(Wang et al., 2015)

presumptive scutellum | third instar larval stage, with Scer\GAL4^pnr-MD237

(Wang et al., 2015)

scutellum | adult stage, with Scer\GAL4^pnr-MD237

(Wang et al., 2015)

wing blade | adult stage, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^en.PU

(Wang et al., 2015)

wing pouch | third instar larval stage, with Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

Detailed Description

Statement

Reference

Expression of Hsap\APLP1^Scer\UAS.cMa driven along the anterior/posterior compartment boundary in third instar larval wing discs by Scer\GAL4^ptc-559.1 or Scer\GAL4^dpp.PU leads to increased cell death in this region, along with a loss of anterior crossvein phenotype in adult fly wings, compared to controls. Expression of Hsap\APLP1^Scer\UAS.cMa driven in the posterior compartment of third instar larval wing discs by Scer\GAL4^en.PU leads to increased cell death in this region, along with a loss of anterior crossvein phenotype in adult fly wings, compared to controls. Expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^sd-SG29.1 leads to extensive cell death in the wing pouch of third instar larvae and produces a blistered wing phenotype in adults. Expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^pnr-MD237 induces cell death in the notum tips of wing discs and leads to a small scutellum phenotype in flies, compared to controls. Expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^elav.PU induces cell death in the ventral nerve cord of third instar larvae. Expression of Hsap\APLP1^Scer\UAS.cMa driven in eye discs of third instar larvae by Scer\GAL4^GMR.PU induces cell death posterior to the morphogenetic furrow.

(Wang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has increased cell death | third instar larval stage phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has increased cell death | third instar larval stage phenotype, suppressible | partially by foxo²¹/foxo[+]

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^sd-SG29.1 has visible phenotype, suppressible by foxo[+]/foxo^Δ94

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^sd-SG29.1 has visible phenotype, suppressible by foxo²¹/foxo[+]

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has increased cell death | third instar larval stage phenotype, suppressible by foxo^KK108590, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has visible phenotype, suppressible by foxo^KK108590, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has visible phenotype, suppressible by foxo[+]/foxo^Δ94

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has visible phenotype, suppressible by foxo²¹/foxo[+]

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has increased cell death | third instar larval stage phenotype, suppressible by Diap1^UAS.cUa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has increased cell death | third instar larval stage phenotype, suppressible | partially by foxo^KK108590, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has visible phenotype, suppressible | partially by foxo^KK108590, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has increased cell death | third instar larval stage phenotype, suppressible | partially by foxo[+]/foxo^Δ94

(Wang et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by foxo²¹/foxo[+]

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^sd-SG29.1 has wing blade | adult stage phenotype, suppressible by foxo[+]/foxo^Δ94

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^sd-SG29.1 has wing blade | adult stage phenotype, suppressible by foxo²¹/foxo[+]

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has presumptive scutellum | third instar larval stage phenotype, suppressible by foxo^KK108590, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has scutellum | adult stage phenotype, suppressible by foxo^KK108590, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible by Diap1^UAS.cUa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has scutellum | adult stage phenotype, suppressible by foxo[+]/foxo^Δ94

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237 has scutellum | adult stage phenotype, suppressible by foxo²¹/foxo[+]

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by foxo^KK108590, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has anterior crossvein | adult stage phenotype, suppressible | partially by foxo^KK108590, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by foxo[+]/foxo^Δ94

(Wang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of BacA\p35^Scer\UAS.cUa or Diap1^Scer\UAS.cUa suppresses the increased cell death induced by expression of Hsap\APLP1^Scer\UAS.cMa driven along the anterior/posterior compartment boundary in third instar larval wing discs by Scer\GAL4^ptc-559.1.

Presence of foxo^Δ94/+ or foxo²¹/+ significantly partially suppresses the increased cell death induced by expression of Hsap\APLP1^Scer\UAS.cMa driven along the anterior/posterior compartment boundary in third instar larval wing discs by Scer\GAL4^ptc-559.1. Co-expression of foxo^KK108590 significantly partially suppresses the increased cell death in third instar larval wing discs and the loss of the anterior crossvein in adult wings induced by expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^ptc-559.1. Presence of foxo^Δ94/+ or foxo²¹/+ suppresses the blistered wing phenotype in flies with expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^sd-SG29.1.

Co-expression of foxo^KK108590 significantly suppresses the increased cell death in the notum tips of third instar larval wing discs and the small scutellum phenotype in adults induced by expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^pnr-MD237. Presence of foxo^Δ94/+ or foxo²¹/+ suppresses the small scutellum phenotype seen with expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^pnr-MD237.

(Wang et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\APLP1^Scer\UAS.cMa

Hsap\APLP1^UAS.cMa

Name Synonyms

Secondary FlyBase IDs

References (2)

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