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General Information
Symbol
Dmel\foxoKK108590
Species
D. melanogaster
Name
FlyBase ID
FBal0235673
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of foxoKK108590 under the control of Scer\GAL4Bx-MS1096 results in male flies with severe wing size and patterning defects.

Expression of foxoKK108590 under the control of Scer\GAL4Bx-MS1096 results in female flies with weak wing size and patterning defects.

Expression via Scer\GAL4wor.PA and Scer\GAL80ase.PN does not prevent the normal cell cycle exit of pupal neuroblasts.

Expression of foxoKK108590 under the control of Scer\GAL4phm.PO results in larvae that undergo the 'critical weight' ecdysone peak at reduced sizes compared to controls in response to starvation. It occurs at the same age as control flies.

Expression of foxoKK108590 under the control of Scer\GAL4phm.PO in starved larvae results in male pharate adults with a slight, but significantly reduced body size compared to controls. Females are similar to controls.

Expression of foxoKK108590 under the control of Scer\GAL4Appl.G1a does not exhibit defects in locomotory ability.

Expression of foxoKK108590 in C-I neurons under the control of Scer\GAL4221 results in ddaD neurons that have an increased number of dendritic branches compared to controls.

Expression of foxoKK108590 in C-IV neurons under the control of Scer\GAL4ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC neurons.

Neuronal knock-down of foxo through expression of foxoKK108590 under the control of Scer\GAL4elav.PLu results in enhanced microtubule stability in neuromuscular junctions compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of uspJF02546 and foxoKK108590 under the control of Scer\GAL4phm.PO enhances the increase in size at which the 'critical weight' ecdysone peak takes place in response to starvation compared to that seen with either transgene alone. The critical weight takes place significantly earlier than in controls.

Co-expression of foxoKK108590 and uspJF02546 under the control of Scer\GAL4phm.PO in starved larvae dramatically enhances the reduction in pharate adult body size seen with either transgene alone.

Xenogenetic Interactions
Statement
Reference

Co-expression of foxoKK108590 significantly partially suppresses the increased cell death in third instar larval wing discs and the loss of the anterior crossvein in adult wings induced by expression of Hsap\APLP1Scer\UAS.cMa driven by Scer\GAL4ptc-559.1. Co-expression of foxoKK108590 significantly suppresses the increased cell death in the notum tips of third instar larval wing discs and the small scutellum phenotype in adults induced by expression of Hsap\APLP1Scer\UAS.cMa driven by Scer\GAL4pnr-MD237.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
foxoKK108590
Name Synonyms
Secondary FlyBase IDs
    References (14)