FlyBase Allele Report: Dmel\Sox14[fl.UAS]

General Information

Symbol

Dmel\Sox14^fl.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0242677

Feature type

allele

Associated gene

Dmel\Sox14

Associated Insertion(s)

Carried in Construct

P{UAS-Sox14.fl}

Also Known As

UAS-Sox14

Key Links

Transgenic product class

cDNA

(Kirilly et al., 2009)

wild_type

(Kirilly et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Kirilly et al., 2009)

wild_type

(Kirilly et al., 2009)

Mutagen

in vitro construct

(Kirilly et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-Sox14.fl}

Cytology

Description

UASt regulatory sequences drive expression of a full-length Sox14 cDNA.

(Kirilly et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Sox14

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4²²¹

(Kirilly et al., 2009)

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

(Kirilly et al., 2009)

Phenotype Manifest In

dendrite, with Scer\GAL4²²¹

(Kirilly et al., 2009)

dendrite, with Scer\GAL4^ppk.1.9

(Kirilly et al., 2009)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4²²¹

(Kirilly et al., 2009)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Kirilly et al., 2009)

Detailed Description

Statement

Reference

Overexpression of Sox14^fl.Scer\UAS under the control of either Scer\GAL4^ppk.1.9 or Scer\GAL4²²¹ results in severe pruning of primary and secondary dendrites by 6 hours APF.

(Kirilly et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ppk.1.9, Sox14^fl.UAS has abnormal neuroanatomy phenotype, suppressible by Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Scer\GAL4²²¹, Sox14^fl.UAS has abnormal neuroanatomy phenotype, suppressible by Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Suppressor of

Statement

Reference

Sox14^fl.UAS/Scer\GAL4^ppk.1.9 is a suppressor | partially of abnormal neuroanatomy phenotype of Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Sox14^fl.UAS/Scer\GAL4²²¹ is a suppressor | partially of abnormal neuroanatomy phenotype of Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Sox14^fl.UAS, Scer\GAL4^109(2)80 is a suppressor of abnormal neuroanatomy phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^109(2)80

(Kirilly et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4²²¹, Sox14^fl.UAS has dendrite phenotype, suppressible by Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Scer\GAL4²²¹, Sox14^fl.UAS has larval dorsal multidendritic neuron ddaC phenotype, suppressible by Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Scer\GAL4^ppk.1.9, Sox14^fl.UAS has dendrite phenotype, suppressible by Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Scer\GAL4^ppk.1.9, Sox14^fl.UAS has larval dorsal multidendritic neuron ddaC phenotype, suppressible by Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Suppressor of

Statement

Reference

Sox14^fl.UAS, Scer\GAL4^109(2)80 is a suppressor of dendrite phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^109(2)80

(Kirilly et al., 2009)

Sox14^fl.UAS, Scer\GAL4^109(2)80 is a suppressor of larval dorsal multidendritic neuron ddaC phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^109(2)80

(Kirilly et al., 2009)

Sox14^fl.UAS/Scer\GAL4^ppk.1.9 is a suppressor | partially of dendrite phenotype of Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Sox14^fl.UAS/Scer\GAL4^ppk.1.9 is a suppressor | partially of larval dorsal multidendritic neuron ddaC phenotype of Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Sox14^fl.UAS/Scer\GAL4²²¹ is a suppressor | partially of dendrite phenotype of Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Sox14^fl.UAS/Scer\GAL4²²¹ is a suppressor | partially of larval dorsal multidendritic neuron ddaC phenotype of Mical¹⁵²⁵⁶

(Kirilly et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of Sox14^fl.Scer\UAS under the control of either Scer\GAL4^ppk.1.9 or Scer\GAL4²²¹ in a homozygous Mical¹⁵²⁵⁶ background has a very mild pruning effect on primary and secondary dendrites by 6 hours APF.

Co-expression of Sox14^fl.Scer\UAS with EcR^{B1-ΔC655.W650A.Scer\UAS} in ddaC neurons under the control of Scer\GAL4^109(2)80 suppresses the excess dendritic arborization found upon expression of EcR^{B1-ΔC655.W650A.Scer\UAS} alone in ddaC neurons under the control of Scer\GAL4^109(2)80.

(Kirilly et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Sox14^fl.UAS/Scer\GAL4^ppk.1.9 rescues Sox14^GD4416

(Loncle and Williams, 2012)

Scer\GAL4^109(2)80/Sox14^fl.UAS rescues Sox14^Δ15/Sox14^Δ13

(Kirilly et al., 2009)

Comments

Co-expression of Sox14^fl.Scer\UAS rescues the dendrite severing defects seen in the ddaC dorsal dendritic arborising neurons of animals expressing Sox14^GD4416 under the control of Scer\GAL4^ppk.1.9 at 18 hours after puparium formation.

(Loncle and Williams, 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sox14^fl.Scer\UAS

Sox14^fl.UAS

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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