FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\numbRNAi.UAS.cTa
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General Information
Symbol
Dmel\numbRNAi.UAS.cTa
Species
D. melanogaster
Name
FlyBase ID
FBal0243185
Feature type
allele
Associated gene
Dmel\numb
Associated Insertion(s)
Carried in Construct
P{UAS-numb.RNAi.T}
Key Links
Transgenic product class
RNAi_reagent
(Tang et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Tang et al., 2005)
Mutagen
in vitro construct
(Tang et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-numb.RNAi.T}
Cytology
Description

dsRNA is generated through two overlapping 1kb fragments with a loop of ~120 nucleotides cloned downstream of UAS regulatory sequences.

(Tang et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
numb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of numbdsRNA.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4sca-537.4 at 18[o]C results in adult flies in which 10 to 20% of the notum external sensory organs contain only four sockets.

      Expression of numbdsRNA.Scer\UAS.T:Hsap\MYC in the SOP lineage, under the control of Scer\GAL4sca-537.4 results in a severe loss of neurons in the PNS.

      (Tang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Klp98AΔ47/+;Scer\GAL4pnr-MD237>numbdsRNA.Scer\UAS.T:Hsap\MYC mutants have a multiple socket phenotype on the notum; this phenotype is suppressed in Klp98AΔ47/Klp98AΔ8;Scer\GAL4pnr-MD237>numbdsRNA.Scer\UAS.T:Hsap\MYC or Klp98AΔ47/Klp98AΔ6;Scer\GAL4pnr-MD237>numbdsRNA.Scer\UAS.T:Hsap\MYC double mutants.

      (Derivery et al., 2015)

      Ectopic scutellar bristle formation in flies expressing spdoScer\UAS.cOa under the control of Scer\GAL4ptc-559.1 is suppressed by co-expression of numbdsRNA.Scer\UAS.T:Hsap\MYC.

      (Babaoglan et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Mmus\NumbΔC.Scer\UAS with numbdsRNA.Scer\UAS.T:Hsap\MYC, both under the control of Scer\GAL4sca-537.4 rescues the numbdsRNA.Scer\UAS.T:Hsap\MYC neuronal-loss phenotype, with the abdominal segments, in particular a1, a3, a5, and a7, no longer exhibiting the neuronal loss found in numbdsRNA.Scer\UAS.T:Hsap\MYC mutants. This rescue of neuron and sheath cells is also observed in other regions of the PNS, including the lateral chordotonal organs.

      Co-expression of Mmus\NumbNPF.DPF.Scer\UAS with numbdsRNA.Scer\UAS.T:Hsap\MYC, both under the control of Scer\GAL4sca-537.4 rescues the numbdsRNA.Scer\UAS.T:Hsap\MYC neuronal-loss phenotype, with the abdominal segments, in particular a1, a3, a5, and a7, no longer exhibiting the neuronal loss found in numbdsRNA.Scer\UAS.T:Hsap\MYC mutants. This rescue of neuron and sheath cells is also observed in other regions of the PNS, including the lateral chordotonal organs.

      Expression of Mmus\NumbCKO.Scer\UAS in the SOP lineage, under the control of Scer\GAL4sca-537.4 failed to suppress the four-socket phenotypes associated with expression of numbdsRNA.Scer\UAS.T:Hsap\MYC.

      (Tang et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      numbRNAi.UAS.cTa
      numbdsRNA.Scer\UAS.T:Hsap\MYC
      numbdsRNA.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)