FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Eps-152
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General Information
Symbol
Dmel\Eps-152
Species
D. melanogaster
Name
FlyBase ID
FBal0243186
Feature type
allele
Associated gene
Dmel\Eps-15
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Tang et al., 2005)
Progenitor genotype
Eps-15EP2513
(Tang et al., 2005)
Cytology
Description

Imprecise excision of P{EP}Eps-15EP2513 generates a deletion covering about 20.5kb of the Eps-15 promoter region and part of the 5' untranslated region.

(Tang et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Eps-152 and Eps-152/Eps-15EP2513 transheterozygous mutants show no increases in lethality or balding.

      (Tang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Eps-15EP2513/Eps-152 is an enhancer of macrochaeta phenotype of H2

      (Tang et al., 2005)

      Eps-15EP2513/Eps-152 is an enhancer of eo sensory structure phenotype of H2

      (Tang et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Eps-152/Eps-15EP2513 transheterozygous background significantly enhances the hair loss phenotype observed in H2 heterozygotes. This enhancement is gene dosage dependent with loss of both copies of Eps-15 increasing the hair loss to 46%, accompanied by increases of nearly four-fold in the number of double sockets and nearly two-fold in the number of areas with no external sensory organs.

      (Tang et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EH12
      (Tang et al., 2005)
      Eps-152
      Name Synonyms
      Secondary FlyBase IDs
        References (1)