FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Eps-15EP2513
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General Information
Symbol
Dmel\Eps-15EP2513
Species
D. melanogaster
Name
FlyBase ID
FBal0131048
Feature type
allele
Associated gene
Dmel\Eps-15
Associated Insertion(s)
P{EP}Eps-15EP2513
Carried in Construct
Also Known As
eps15EP2513, EP2513
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}Eps-15EP2513
Cytology
Description

Insertion in the 5' untranslated region.

(Koh et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  severe acute respiratory syndrome
      modeled by HCoV-SARS\3aUAS.CUHK-W1.EGFP
      (Wong et al., 2005)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous third instar larvae show a mildly reduced dye uptake at the neuromuscular junction during nerve stimulation compared to controls, indicating a defect in endocytosis.

      (Koh et al., 2007)

      Primary cultured haemocytes from mutant third instar larvae internalise maleylated bovine serum albumin (mBSA) normally.

      (Korolchuk et al., 2007)

      Homozygous Eps-15EP2513 flies survive to the pupal stage, although approximately 40% fail to eclose. Those that do eclose exhibit no apparent behavioral abnormalities and are fertile.

      Eps-15EP2513 mutants do not exhibit any defects in the SOP lineage on the notum and the scutellum, although some (approximately 10%) have small balding patches on abdominal segments, with neither hairs nor sockets.

      Eps-15EP2513/Df(2R)Dll-MP and Eps-152/Eps-15EP2513 mutants show no increases in lethality or balding.

      (Tang et al., 2005)

      Homozygous mutants show reduced survival to adult stages. Mutant larvae are sluggish and have an abnormal body posture. Prolonged stimulation of neuromuscular junctions (NMJs) leads to a more severe run-down in amplitude of excitatory junction potentials (EJPs) in mutant larvae than in wild-type. This indicates a possible defect in replenishment of synaptic vesicles.

      (Wairkar et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Eps-15EP2513 has lethal | pupal stage phenotype, suppressible by Su(H)[+]/Su(H)1

      (Tang et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Eps-15EP2513/Eps-152 is an enhancer of macrochaeta phenotype of H2

      (Tang et al., 2005)

      Eps-15EP2513/Eps-152 is an enhancer of eo sensory structure phenotype of H2

      (Tang et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Su(H)1 heterozygosity suppresses the lethality found in Eps-15EP2513 homozygotes. These flies do not exhibit any apparent morphological or behavioral defects.

      A Eps-152/Eps-15EP2513 transheterozygous background significantly enhances the hair loss phenotype observed in H2 heterozygotes. This enhancement is gene dosage dependent with loss of both copies of Eps-15 increasing the hair loss to 46%, accompanied by increases of nearly four-fold in the number of double sockets and nearly two-fold in the number of areas with no external sensory organs.

      (Tang et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (11)