FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Spps1
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General Information
Symbol
Dmel\Spps1
Species
D. melanogaster
Name
FlyBase ID
FBal0246639
Feature type
allele
Associated gene
Dmel\Spps
Associated Insertion(s)
TI{TI}Spps1
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Brown and Kassis, 2010)
Mutagen
I-SceI
(Brown and Kassis, 2010)
FLPase
(Brown and Kassis, 2010)
ends-out gene targeting
(Brown and Kassis, 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}Spps1
Cytology
Description

The endogenous Spps genomic region has been replaced by a marker composed of Avic\GFP expressed under the control of the arm promoter.

(Brown and Kassis, 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most homozygotes die as pharate adults, though some hatch and die shortly thereafter. Spps1/Df(3R)Exel6198 or Spps1/Df(3R)crb87-4 flies die at a similar stage. Aside from some wing defects (most flies do not open the wings at all), there is no other morphological defect - homeotic transformations are not observed. The phenotype of maternal-zygotic mutants is exactly the same as zygotic mutants.

      (Brown and Kassis, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Spps1/Spps1 is an enhancer of lethal | pharate adult stage | recessive phenotype of pho1

      (Brown and Kassis, 2010)
      Other
      Statement
      Reference

      Spps1, pho1 has abnormal body size | larval stage phenotype

      (Brown and Kassis, 2010)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Spps1/Spps1 is a non-enhancer of sex comb | increased number phenotype of Psc1

      (Brown and Kassis, 2010)

      Spps1/Spps1 is a non-enhancer of sex comb | increased number phenotype of Pc4

      (Brown and Kassis, 2010)
      Other
      Statement
      Reference

      Spps1, pho1 has imaginal disc phenotype

      (Brown and Kassis, 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Polycomb-group response element (PRE)-mediated silencing of w+mC expression in wen.8 heterozygotes or homozygotes is suppressed when flies are also homozygous for Spps1.

      Polycomb-group response element (PRE)-mediated silencing of w+mC expression in wen.PRE heterozygotes or homozygotes is suppressed when flies are also homozygous for Spps1.

      Polycomb-group response element (PRE)-mediated silencing of w+mC expression in wUbx.PRE.D heterozygotes or homozygotes is suppressed when flies are also homozygous for Spps1.

      pho1, Spps1 double mutants die earlier in development than either single mutant: single mutants die as pharates, whereas double mutants die as third instar larvae or often at earlier stages. Double mutant larvae are often abnormally small and have misshapen imaginal discs.

      (Brown and Kassis, 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Spps1
      (Brown and Kassis, 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)