FlyBase Allele Report: Scer\GAL4[nompC.PC]

General Information

Symbol

Scer\GAL4^nompC.PC

Species

S. cerevisiae

Name

no mechanoreceptor potential C promoter construct of Cheng

FlyBase ID

FBal0246936

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{nompC-GAL4.C}

Also Known As

nompC-Gal4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Cheng et al., 2010)

Progenitor genotype

Carried in construct

P{nompC-GAL4.C}

Cytology

Description

nompC promoter sequences regulate expression of a GAL4 driver.

(Cheng et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

nompC

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval dorsal multidendritic neuron ddaD

(Cheng et al., 2010)

larval dorsal multidendritic neuron ddaE

(Cheng et al., 2010)

abdominal dorsal bipolar neuron dbp

(Cheng et al., 2010)

abdominal lch1 neuron

(Cheng et al., 2010)

larval abdominal lch5 neuron

(Cheng et al., 2010)

abdominal ventral bipolar dendrite neuron vbd

(Cheng et al., 2010)

abdominal vch2 neuron

(Cheng et al., 2010)

abdominal vch1 neuron

(Cheng et al., 2010)

abdominal ventral multidendritic neuron v'dap

(Cheng et al., 2010)

adult stage

chordotonal organ of leg

(Cheng et al., 2010)

mechanosensory neuron | subset

(Cheng et al., 2010)

mechanosensory neuron | subset of haltere

(Cheng et al., 2010)

Johnston organ neuron | subset

(Cheng et al., 2010)

Additional Information

Statement

Reference

Marker for

Reflects expression of

nompC

(Cheng et al., 2010)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal feeding behavior | adult stage | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(Zhou et al., 2019)

abnormal feeding behavior | adult stage | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}, Scer\GAL4^Gr66a.1.8

(Zhou et al., 2019)

abnormal neurophysiology | cell non-autonomous | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(Zhou et al., 2019)

Phenotype Manifest In

adult motor neuron | cell non-autonomous | conditional, with Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus}

(Zhou et al., 2019)

Detailed Description

Statement

Reference

Optogenetic activation (using Cnoc\ChR1::Csub\ChR^{CsChrimson.IVS.20xUAS.Venus} with 617 nm (red) light) of Scer\GAL4^nompC.PC cells, or the combination of Scer\GAL4^nompC.PC and Scer\GAL4^Gr66a.1.8 cells, in adults results in induction of proboscis retraction due to stimulation during feeding, compared to controls; in the case of Scer\GAL4^nompC.PC cell activation alone there is no induction of labellar spread, compared to controls; activation of Scer\GAL4^nompC.PC cells in the labellum results in activation of one pair of Scer\GAL4^GMR58H01-expressing motor neurons in the brain with a 2 ms delay, compared to baseline.

(Zhou et al., 2019)

Inhibition (using Ctet\tetX^TNT-LC.UAS) of Scer\GAL4^nompC.PC cells in starved adult males does not affect preference for softer sucrose-containing agarose, compared to controls.

(Sánchez-Alcañiz et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^nompC.PC/nompC^L.UAS rescues nompC¹/nompC³

(Gong et al., 2013)

Scer\GAL4^nompC.PC/nompC^E1511A.UAS rescues nompC¹/nompC³

(Gong et al., 2013)

Scer\GAL4^nompC.PC/nompC^L.UAS rescues nompC¹/nompC³

(Cheng et al., 2010)

Partially rescues

Scer\GAL4^nompC.PC/nompC^D1516A.UAS partially rescues nompC¹/nompC³

(Gong et al., 2013)

Fails to rescue

Scer\GAL4^nompC.PC/tutl^RE40452.UAS fails to rescue tutl²³

(Zhou et al., 2012)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Gal4^nompC

(Hu et al., 2020)

Scer\GAL4^nompC.PC

Name Synonyms

no mechanoreceptor potential C promoter construct of Cheng

Secondary FlyBase IDs

References (11)

Report Sections

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