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General Information
Symbol
Dmel\tutlRE40452.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0290261
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-tutl
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of tutl full-length coding sequences.

UASt regulatory sequences drive expression of a 5.2kb EcoRI/BamHI fragment from the tutl RE40452 cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

dendrite & dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9

Detailed Description
Statement
Reference

Expression of tutlScer\UAS.cLa under the control of Scer\GAL4ppk.1.9 reduces dendritic branching in ddaC neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The defect in navigational response to gentle touch which is seen in homozygous tutl23 larvae is rescued by expression of tutlRE40452.Scer\UAS under the control of one of Scer\GAL4elav-C155, Scer\GAL4Appl.G1a or Scer\GAL4Cha.7.4. Expression under the control of one of Scer\GAL4VGlut-OK371, Scer\GAL4Ddc.PL, Scer\GAL4eve.RN2, Scer\GAL4G11-1, Scer\GAL4ftz.ng, Scer\GAL4D42, Scer\GAL4TrpA1.PR, Scer\GAL45-HTR1B, Scer\GAL4c81, Scer\GAL45-40, Scer\GAL4nompC.PC, Scer\GAL4iav.PK, Scer\GAL4pain-GAL4 or Scer\GAL4ppk.1.9 does not rescue the mutant phenotype.

Expression of tutlRE40452.Scer\UAS under the control of Scer\GAL4elav-C155 from the beginning of the larval stage onwards is sufficient to rescue the defect in navigational response to gentle touch seen in homozygous tutl23 larvae, while limiting expression to the embryonic stage results in a failure of rescue (the temperature-sensitive Scer\GAL80ts.╬▒Tub84B allele has been used to limit the stage of expression).

Expression of tutlScer\UAS.cFa under the control of Scer\GAL4GMR.long rescues the mild tiling phenotype found in tutlk14703/tutl23 R7 terminals.

Expression of tutlScer\UAS.cLa under the control of Scer\GAL4221 restores the number of dendrite branch termini per cell to wild-type levels in tutl01085/tutl23 ddaE neurons.

Expression of tutlScer\UAS.cLa under the control of Scer\GAL4elav-C155 rescues the viability of tutl01085/tutl23 mutants to 93%.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
tutlRE40452.Scer\UAS
tutlRE40452.UAS
tutlScer\UAS.cFa
tutlScer\UAS.cLa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Long
Secondary FlyBase IDs
  • FBal0241229
  • FBal0243340
References (4)