FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bazS980A.UAS.GFP
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General Information
Symbol
Dmel\bazS980A.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0247042
Feature type
allele
Associated gene
Dmel\baz
Associated Insertion(s)
Carried in Construct
P{UAS-baz.S980A.GFP}
Key Links
Transgenic product class
missense_variant
(Krahn et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Krahn et al., 2010)
Mutagen
in vitro construct
(Krahn et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-baz.S980A.GFP}
Cytology
Description

UAS regulatory sequences drive expression of baz carrying a S980A substitution, tagged at the N-terminus with GFP.

(Krahn et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
baz
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing bazS980A.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4da.G32 display severely disrupted epithelial morphogenesis and degeneration of the epidermis. Mutant embryos are open dorsally, and internal organs including the foregut and midgut protrude to the outside. Many epidermal cells round up and die by apoptosis.

      Expression of bazS980A.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4arm.PS results in only little scraps of cuticle formation.

      (Krahn et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of crbintra.Scer\UAS and bazS980A.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4da.G32 results in the same phenotype as overexpression of bazS980A.Scer\UAS.T:Avic\GFP alone. Only little scraps of embryonic cuticle are observed.

      The cuticle defects observed when bazS980A.Scer\UAS.T:Avic\GFP is expressed under the control of Scer\GAL4arm.PS are strongly suppressed in a l(2)gl4 or scrib673 mutant background.

      (Krahn et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bazS980A.Scer\UAS.T:Avic\GFP
      bazS980A.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)