FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\htsnull
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General Information
Symbol
Dmel\htsnull
Species
D. melanogaster
Name
FlyBase ID
FBal0248988
Feature type
allele
Associated gene
Dmel\hts
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Ohler et al., 2011)
Mutagen
FLPase
(Ohler et al., 2011)
Progenitor genotype
P{RS5}hts5-SZ-4016
(Ohler et al., 2011)
PBac{WH}htsf02762
(Ohler et al., 2011)
Cytology
Description

Removes almost the complete hts coding sequence.

(Ohler et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The few htsnull/Df(2R)BSC26 transheterozygous adult escapers exhibit rough eyes and have no wing defects. Larval garland nephrocytes frequently show a discontinuous slit diaphragm.

      (Gonçalves et al., 2018)

      Recessive lethal at 25[o]C. A few escapers emerge when flies are raised at 18[o]C.

      Flies with htsnull mutant eyes show a strongly defective phenotype in the medulla. The overall structure is disrupted. Axons lose their regular array and clump together. Some R8 axons overshoot M3 or stop prematurely. Abnormally thick bulb-like structures at the axon termini and at the M1 layer are observed.

      (Ohler et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The number and size of R8 axon swellings seen in Scer\GAL4GMR.PU, gogoScer\UAS.T1 animals is increased in a htsnull/+ background.

      (Ohler et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference

      htsnull/Df(2R)BSC26 transheterozygotes rescued to adulthood by the co-expression of Hsap\ADD1UAS.Tag:HA with either Hsap\ADD3UAS.Tag:V5 or Hsap\ADD3E659Q.UAS.Tag:V5 under the control of Scer\GAL4αTub84B.PL show a mostly normal heart function: significant decrease in diastolic diameter but not measurable changes in heart period, cardiac output, fractional shortening, or arrhythmia index). There are no defects in nephrocyte number.

      (Gonçalves et al., 2018)
      Complementation and Rescue Data
      Partially rescued by

      htsnull is partially rescued by htsGMR.Add1

      (Ohler et al., 2011)

      htsnull is partially rescued by htsGMR.PD

      (Ohler et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      htsnull
      (Gonçalves et al., 2018, Ohler et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)