FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\htsGMR.Add1
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General Information
Symbol
Dmel\htsGMR.Add1
Species
D. melanogaster
Name
FlyBase ID
FBal0248989
Feature type
allele
Associated gene
Dmel\hts
Associated Insertion(s)
Carried in Construct
P{GMR-hts.Add1}
Key Links
Transgenic product class
cDNA
(Ohler et al., 2011)
wild_type
(Ohler et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ohler et al., 2011)
wild_type
(Ohler et al., 2011)
Mutagen
in vitro construct
(Ohler et al., 2011)
Progenitor genotype
Carried in construct
P{GMR-hts.Add1}
Cytology
Description

The GMR promoter drives expression of a cDNA encoding the 718 aa 'Add1' isoform of the hts product. (In addition to the common first 472 N-terminal amino acids, 'Add1' contains the Adducin tail including the MARCKS domain.)

(Ohler et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
hts
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      R8 axons show abnormally thick swellings at the M1 layer.

      (Ohler et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      htsGMR.Add1 has photoreceptor cell R8 phenotype, suppressible by gogoScer\UAS.T1/Scer\GAL4GMR.PU

      (Ohler et al., 2011)
      Suppressor of
      Statement
      Reference

      htsGMR.Add1 is a suppressor of photoreceptor cell R8 phenotype of Scer\GAL4GMR.PU, gogoScer\UAS.T1

      (Ohler et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      R8 axon swelling seen in Scer\GAL4GMR.PU, gogoScer\UAS.T1 animals is suppressed when htsGMR.Add1 is also present. Likewise, the R8 axon swelling seen in htsGMR.Add1 animals is suppressed when Scer\GAL4GMR.PU, gogoScer\UAS.T1 is present.

      (Ohler et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      htsGMR.Add1 partially rescues hts01103/Df(2R)BSC26

      (Ohler et al., 2011)

      htsGMR.Add1 partially rescues htsnull

      (Ohler et al., 2011)
      Comments

      htsGMR.Add1 eliminates the medulla defects of hts01103 hemizygotes to a large extent.

      htsGMR.Add1 partially rescues the medulla defects seen in htsnull eyes.

      (Ohler et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      htsGMR.Add1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)