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General Information
Symbol
Dmel\Ir8a1
Species
D. melanogaster
Name
FlyBase ID
FBal0249364
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The entire Ir8a gene has been replaced by a w+* marker.

Insertion components
TI{TI}Ir8a1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ir8a1/Ir8a1 mutant females do not exhibit a significant reduction in feeding preference index for 1% yeast extract versus 5mM sucrose solution, as compared to wild type.

In olfactory preference assays for polyamines, Ir8a1/Ir8a1 flies do not show any significant difference in their attraction to putrescine or cadaverine, as compared to wild type, and females do not show any significant difference in their aversion to oviposit on polyamine-rich substrate (plain, sugar-free 1% agarose supplemented with either putrescine or cadaverine) versus non-supplemented substrate, as compared to wild type.

Ir8a1 mutant adults have no alteration in circadian clock entrainment index for locomotor activity rhythms following a 7 h delay under 25[o] C:27 [o]C temperature cycles in constant light conditions, compared to controls.

Ir8a1 mutants exhibit a reduced DC4 and DP1M glomeruli response to odorants.

Ir8a1 mutant flies demonstrate a significantly reduced avoidance to acetic acid, compared to controls.

Homozygous Ir8a1 mutant animals are viable and fertile.

Ir8a1 mutant class 4 (ac4) coeloconic sensilla lack electrophysiological responsiveness to phenylacetaldehyde, while phenylethyl amine responses are unchanged.

Ir8a1 mutant class 3 (ac3) coeloconic sensilla lack electrophysiological responsiveness to propionic acid.

Electrophysiological responses to γ-hexalactone persist in Ir8a1 mutant class 3 (ac3) coeloconic sensilla.

Electrophysiological responses to acetic acid, but not to 1,4-diaminobutane, are abolished in Ir8a1 mutant class 2 (ac2) coeloconic sensilla.

Electrophysiological responses to ammonia are retained in Ir8a1 mutant class 1 (ac1) coeloconic sensilla.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

Ir8a1 has viable phenotype, non-suppressible by Ir25a2

Ir8a1 has fertile phenotype, non-suppressible by Ir25a2

Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Ir8a1, Ir25a2 double mutant animals are viable and fertile.

The increased avoidance behaviour of Orco1 homozygotes to acetic acid is suppressed by Ir8a1/Ir8a1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Ir8aScer\UAS.cAa driven by Scer\GAL4Ir8a.PA rescues the odor-evoked electrophysiological response phenotypes in Ir8a1 mutant coeloconic sensilla.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (16)