FlyBase Allele Report: Dmel\Ir8a[1]

General Information

Symbol

Dmel\Ir8a¹

Species

D. melanogaster

Name

FlyBase ID

FBal0249364

Feature type

allele

Associated gene

Dmel\Ir8a

Associated Insertion(s)

TI{TI}Ir8a¹

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

ends-out gene targeting

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Abuin et al., 2011)

Mutagen

ends-out gene targeting

(Abuin et al., 2011)

Progenitor genotype

Associated Insertion(s)

TI{TI}Ir8a¹

Cytology

Description

The entire Ir8a gene has been replaced by a w^+* marker.

(Abuin et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | progressive

(Long et al., 2024)

abnormal neurophysiology

(Abuin et al., 2011)

abnormal smell perception

(Ai et al., 2013)

decreased cell number | adult stage | progressive

(Long et al., 2024)

fertile

(Abuin et al., 2011)

viable

(Abuin et al., 2011)

Phenotype Manifest In

adult olfactory receptor neuron Ir64a | decreased number

(Long et al., 2024)

coeloconic sensillum of antennal segment 3

(Abuin et al., 2011)

Detailed Description

Statement

Reference

Ir8a¹/Ir8a¹ mutant females do not exhibit a significant reduction in feeding preference index for 1% yeast extract versus 5mM sucrose solution, as compared to wild type.

(Ganguly et al., 2017)

In olfactory preference assays for polyamines, Ir8a¹/Ir8a¹ flies do not show any significant difference in their attraction to putrescine or cadaverine, as compared to wild type, and females do not show any significant difference in their aversion to oviposit on polyamine-rich substrate (plain, sugar-free 1% agarose supplemented with either putrescine or cadaverine) versus non-supplemented substrate, as compared to wild type.

(Hussain et al., 2016)

Ir8a¹ mutant adults have no alteration in circadian clock entrainment index for locomotor activity rhythms following a 7 h delay under 25[o] C:27 [o]C temperature cycles in constant light conditions, compared to controls.

(Chen et al., 2015)

Ir8a¹ mutants exhibit a reduced DC4 and DP1M glomeruli response to odorants.

Ir8a¹ mutant flies demonstrate a significantly reduced avoidance to acetic acid, compared to controls.

(Ai et al., 2013)

Homozygous Ir8a¹ mutant animals are viable and fertile.

Ir8a¹ mutant class 4 (ac4) coeloconic sensilla lack electrophysiological responsiveness to phenylacetaldehyde, while phenylethyl amine responses are unchanged.

Ir8a¹ mutant class 3 (ac3) coeloconic sensilla lack electrophysiological responsiveness to propionic acid.

Electrophysiological responses to γ-hexalactone persist in Ir8a¹ mutant class 3 (ac3) coeloconic sensilla.

Electrophysiological responses to acetic acid, but not to 1,4-diaminobutane, are abolished in Ir8a¹ mutant class 2 (ac2) coeloconic sensilla.

Electrophysiological responses to ammonia are retained in Ir8a¹ mutant class 1 (ac1) coeloconic sensilla.

(Abuin et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Ir8a¹ has viable phenotype, non-suppressible by Ir25a²

(Abuin et al., 2011)

Ir8a¹ has fertile phenotype, non-suppressible by Ir25a²

(Abuin et al., 2011)

Suppressor of

Statement

Reference

Ir8a¹/Ir8a¹ is a suppressor of abnormal smell perception phenotype of Orco¹

(Silbering et al., 2011)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Ir8a¹, Ir25a² double mutant animals are viable and fertile.

(Abuin et al., 2011)

The increased avoidance behaviour of Orco¹ homozygotes to acetic acid is suppressed by Ir8a¹/Ir8a¹.

(Silbering et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ir8a¹ is rescued by Ir8a^UAS.cAa/Scer\GAL4^Ir8a.PA

(Abuin et al., 2011)

Ir8a¹ is rescued by Ir8a^+mSa

(Silbering et al., 2011)

Comments

Expression of Ir8a^Scer\UAS.cAa driven by Scer\GAL4^Ir8a.PA rescues the odor-evoked electrophysiological response phenotypes in Ir8a¹ mutant coeloconic sensilla.

(Abuin et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

41744

w^* TI{TI}Ir8a¹; Bl¹ L²/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

IR8a¹

(Enjin et al., 2016, Hussain et al., 2016, Chen et al., 2015, Ramdya et al., 2015, Min et al., 2013, Abuin et al., 2011, Silbering et al., 2011)

Ir8a¹

(Nhuchhen Pradhan et al., 2025, Long et al., 2024, Pandey et al., 2024, Pradhan et al., 2024, Sang et al., 2024, Task et al., 2022, Dhakal et al., 2021, Abuin et al., 2019, Steck et al., 2018, Ahn et al., 2017, Ganguly et al., 2017, Hueston et al., 2016, Knecht et al., 2016, Ni et al., 2016, Ai et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (25)

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