FlyBase Allele Report: Scer\GAL4[GMR24E12]

General Information

Symbol

Scer\GAL4^GMR24E12

Species

S. cerevisiae

Name

FlyBase ID

FBal0250855

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{GMR24E12-GAL4}

Also Known As

R24E12

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Pfeiffer et al., 2011.2.9)

Progenitor genotype

Carried in construct

P{GMR24E12-GAL4}

Cytology

Description

A 3387 base pair fragment from the flanking non-coding or intronic region of CG30106 is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)

Allele components

Component

Use(s)

Regulatory region(s)

GMR24E12

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval mushroom body octopaminergic/tyraminergic neuron e1

(Saumweber et al., 2018)

larval mushroom body output neuron j2

(Saumweber et al., 2018)

Additional Information

Statement

Reference

ScerGAL4^GMR24E12 drives expression in mushroom body extrinsic neurons, including dopaminergic PAM neurons 13 and 14 and mushroom body output neuron 5, that innervate mushroom body gamma lobe slices 1, 2 and 4, nd mushroom body beta' lobe slice 1.

(Shuai et al., 2015)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | adult stage, with Ctet\tetX^TNT-LC.UAS

(Shuai et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Inhibition (using Ctet\TeTxLC^TNT.UAS) of Scer\GAL4^GMR24E12 neurons, in combination with a Gal80[ts] transgene to restrict expression to 1 day prior to training and testing, significantly improves 3 hour aversive olfactory memory, compared to controls.

(Shuai et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

49084

w¹¹¹⁸; P{GMR24E12-GAL4}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^GMR24E12

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close