FB2026_02 , released June 18, 2026
Allele: Scer\GAL4GMR30G08
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General Information
Symbol
Scer\GAL4GMR30G08
Species
S. cerevisiae
Name
FlyBase ID
FBal0251426
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{GMR30G08-GAL4}
Also Known As
R30G08
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Pfeiffer et al., 2011.2.9)
Progenitor genotype
Carried in construct
P{GMR30G08-GAL4}
Cytology
Description

A 4483 base pair fragment from the flanking non-coding or intronic region of ple is fused upstream of a Drosophila core synthetic promoter (DSCP) that is followed by sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)
Allele components
Component
Use(s)
Regulatory region(s)
GMR30G08
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      larval mushroom body dopaminergic neuron h1
      (Saumweber et al., 2018, Rohwedder et al., 2016)
      larval mushroom body dopaminergic neuron i1
      (Saumweber et al., 2018, Rohwedder et al., 2016)
      larval mushroom body dopaminergic neuron k1
      (Saumweber et al., 2018, Rohwedder et al., 2016)
      wandering third instar larval stage
      mushroom body extrinsic neuron | subset
      (Li et al., 2014)
      adult stage
      mushroom body extrinsic neuron | subset
      (Li et al., 2014)
      adult brain | restricted
      (Shuai et al., 2015)
      mushroom body extrinsic neuron
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 3
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 4
      (Shuai et al., 2015)
      mushroom body gamma lobe slice 5
      (Shuai et al., 2015)
      mushroom body beta lobe slice 1
      (Shuai et al., 2015)
      mushroom body beta lobe slice 2
      (Shuai et al., 2015)
      mushroom body beta' lobe slice 1
      (Shuai et al., 2015)
      mushroom body beta' lobe slice 2
      (Shuai et al., 2015)
      mushroom body alpha lobe slice 1
      (Shuai et al., 2015)
      Additional Information
      Statement
      Reference

      ScerGAL4GMR30G08 drives expression in a subset of ple positive larval dopaminergic pPAM neurons. Expression in larval dopaminergic pPAM2 neuron is stochastic and very rare.

      (Rohwedder et al., 2016)

      ScerGAL4GMR30G08 drives expression in mushroom body extrinsic neurons that innervate mushroom body gamma lobe slices 3, 4 and 5, mushroom body beta lobe slices 1 and 2, mushroom body beta' lobe slices 1 and 2 and mushroom body alpha lobe slice 1.

      (Shuai et al., 2015)

      In the wandering third instar larva ScerGAL4GMR30G08 drives expression in two pairs of mushroom body extrinsic neurons, in the adult labeling is detected in a small cluster of these neurons.

      (Li et al., 2014)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4GMR30G08 neurons in adults results in a significant reduction in wind-induced suppression of locomotion, compared to controls, with no effect on basal walking speed.

      (Tsubouchi et al., 2017)

      Ablation (using hidUAS.cUa and rprUAS.cUa) of Scer\GAL4GMR30G08 neurons does not significantly affect short-term appetitive olfactory memory following training with fructose, arabinose or sorbitol, compared to controls.

      (Rohwedder et al., 2016)

      Inhibition (using Hsap\KCNJ2UAS.EGFP) of Scer\GAL4GMR30G08 neurons, in combination with a Gal80[ts] transgene to restrict expression to 1 day prior to training and testing, does not affect 3 hour aversive olfactory memory, compared to controls.

      (Shuai et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4GMR30G08
      Name Synonyms
      Secondary FlyBase IDs
        References (7)