FlyBase Allele Report: Dmel\Ca-α1D[HMS00294]

General Information

Symbol

Dmel\Ca-α1D^HMS00294

Species

D. melanogaster

Name

FlyBase ID

FBal0257190

Feature type

allele

Associated gene

Dmel\Ca-α1D

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00294}

Also Known As

Ca-α1D-RNAi, UAS-Ca-α1D-RNAi, Dmca1D RNAi, UAS-Ca-α1D RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00294}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00294

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{695.UAS.Tag:MYC}

(Shao et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^Proc

(Hsu et al., 2020)

Phenotype Manifest In

larval RP2 motor neuron | larval stage, with Scer\GAL4^Proc

(Hsu et al., 2020)

muscle cell of A1-7 lateral longitudinal muscle 1 | larval stage, with Scer\GAL4^Proc

(Hsu et al., 2020)

type Is terminal bouton | larval stage, with Scer\GAL4^Proc

(Hsu et al., 2020)

Detailed Description

Statement

Reference

Expression of Ca-α1D^HMS00294 under the control of Scer\GAL4^Proc leads to a decrease in locomotion of third instar larvae.

During physiological activation, expression of Ca-α1D^HMS00294 under the control of Scer\GAL4^Proc leads to a decrease in Ca[2+] transients in larval RP2 motor neuron type Is boutons (on muscle 4).

Expression of Ca-α1D^HMS00294 under the control of Scer\GAL4^Proc leads to a decrease in neuropeptide (Dilp2-GFP) release in type Is boutons (on muscle 4) upon activation of RP2 motor neuron via exposure to high potassium.

(Hsu et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Scer\GAL4^elav.PU/Ca-α1D^HMS00294 is a non-suppressor of abnormal neurophysiology phenotype of Ih^f03355

(Hu et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33413

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00294}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ca-α1D^HMS00294

Ca-α1Dⁱ

(Liu et al., 2022)

Ca-αID^RNAi

(Metwally et al., 2019)

αID^RNAi

(Metwally et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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