FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MarfRNAi.CDS.UAS
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General Information
Symbol
Dmel\MarfRNAi.CDS.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0258604
Feature type
allele
Associated gene
Dmel\Marf
Associated Insertion(s)
Carried in Construct
P{UAS-Marf.RNAi.CDS}
Key Links
Transgenic product class
RNAi_reagent
(Deng et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Deng et al., 2008)
Mutagen
in vitro construct
(Deng et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Marf.RNAi.CDS}
Cytology
Description

UAS regulatory sequences drive expression of a miRNA targeted to the Marf coding region.

(Deng et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Marf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MarfmiRNA.CDS.Scer\UAS under the control of Scer\GAL4Mef2.PR results in mitochondrial fragmentation (they are smaller and rounder than normal) in the indirect flight muscles. The mitochondria also have irregular cristae.

      (Deng et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4Mef2.PR/MarfRNAi.CDS.UAS is a suppressor of visible phenotype of Pink15

      (Deng et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of MarfmiRNA.CDS.Scer\UAS under the control of Scer\GAL4elav.PU is sufficient to restore a normal filamentous mitochondrial network in Drp11/Drp12 flies.

      Expression of MarfmiRNA.CDS.Scer\UAS under the control of Scer\GAL4elav.PU does not rescue the abnormal mitochondrial morphology of Df(3L)Pmi-PGRP-LD flies.

      (Rival et al., 2011)

      Expression of MarfmiRNA.CDS.Scer\UAS under the control of Scer\GAL4Mef2.PR suppresses the defects in mitochondrial morphology that are seen in the indirect flight muscles of Pink15 mutants. The defects in wing posture and indirect flight muscle degeneration phenotypes are also suppressed.

      Expression of MarfmiRNA.CDS.Scer\UAS under the control of Scer\GAL4how-24B suppresses the defects in mitochondrial morphology that are seen in the indirect flight muscles of park25 mutants. The indirect flight muscle degeneration phenotype is also suppressed.

      (Deng et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MarfRNAi.CDS.UAS
      MarfmiRNA.CDS.Scer\UAS
      MarfmiRNA.CDS.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (6)