FlyBase Allele Report: Dmel\Sln[KK104306]

General Information

Symbol

Dmel\Sln^KK104306

Species

D. melanogaster

Name

FlyBase ID

FBal0259332

Feature type

allele

Associated gene

Dmel\Sln

Associated Insertion(s)

Carried in Construct

P{KK104306}

Also Known As

Sln RNAi, UAS-Sln RNAi KK104306

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK104306}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK104306

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased efficacy of memory | adult stage | calorie restriction conditional, with Scer\GAL4^VT030559

(Silva et al., 2022)

lethal, with Scer\GAL4^repo.PU

(Volkenhoff et al., 2015)

visible, with Scer\GAL4^nSyb.PS

(Volkenhoff et al., 2015)

Phenotype Manifest In

wing, with Scer\GAL4^nSyb.PS

(Volkenhoff et al., 2015)

Detailed Description

Statement

Reference

Adults expressing Sln^KK104306 for 2 days under the combined control of Scer\GAL4^VT030559 and Gal80[ts] (for temporal control of expression) exhibit decreased associative olfactory memory under starvation conditions, but not when fed.

(Silva et al., 2022)

Flies with expression of Sln^KK104306 driven by Scer\GAL4^nSyb.PS have folded wings.

(Volkenhoff et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Sln^KK104306/Scer\GAL4^ppk.PU is a non-enhancer of abnormal wound healing | larval stage phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

Suppressor of

Statement

Reference

Sln^KK104306, Scer\GAL4^repo is a suppressor | partially of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of Marf^B

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of sicily^E

(Liu et al., 2017)

NOT Suppressor of

Statement

Reference

Sln^KK104306/Scer\GAL4^ppk.PU is a non-suppressor of abnormal wound healing | larval stage phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Sln^KK104306/Scer\GAL4^ppk.PU is a non-enhancer of larval multidendritic class IV neuron phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

Suppressor of

Statement

Reference

Sln^KK104306, Scer\GAL4^repo is a suppressor | partially of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of adult optic lobe glial cell | somatic clone phenotype of Marf^B

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of lipid droplet | somatic clone | adult stage phenotype of Marf^B

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of Marf^B

(Liu et al., 2017)

Sln^KK104306, Scer\GAL4^nSyb.PS is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of SREBP^UAS.cKa, Scer\GAL4^nSyb.PS

(Liu et al., 2017)

Sln^KK104306, Scer\GAL4^nSyb.PS is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of SREBP^UAS.cKa, Scer\GAL4^nSyb.PS

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^nSyb.PS is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of Scer\GAL4^nSyb.PS, bsk^UAS.cBa

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^nSyb.PS is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of Scer\GAL4^nSyb.PS, bsk^UAS.cBa

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^elav.PLu is a suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^elav.PLu is a suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of adult optic lobe glial cell | somatic clone phenotype of sicily^E

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of lipid droplet | somatic clone | adult stage phenotype of sicily^E

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^ey.PU is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of sicily^E

(Liu et al., 2017)

NOT Suppressor of

Statement

Reference

Sln^KK104306/Scer\GAL4^ppk.PU is a non-suppressor of larval multidendritic class IV neuron phenotype of Myc^QUAS.cPa, Ncra\QF^repo

(Li et al., 2020)

Sln^KK104306/Scer\GAL4^54C is a non-suppressor of adult optic lobe glial cell | cell non-autonomous phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Sln^KK104306/Scer\GAL4^54C is a non-suppressor of lipid droplet | cell non-autonomous | adult stage phenotype of ND-42^ninaE.GD6220

(Liu et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is not suppressed by Scer\GAL4^54C-driven (glial) expression of Sln^KK104306 while expression under the control of the neuronal Scer\GAL4^elav.PLu driver efficiently rescues the phenotype.

Expression of Sln^KK104306 in the ey>flip whole-eye clones mutant for either sicily^E or Marf^B ameliorates the lipid droplet accumulation in retinal glial cells in adult flies and also improves the photoreceptor degeneration phenotype.

The accumulation of lipid droplets in the retinal glia of adult flies expressing either SREBP^UAS.cKa or bsk^Scer\UAS.cBa under the control of Scer\GAL4^nSyb.PS is significantly suppressed by co-expression of Sln^KK104306.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v109464

P{KK104306}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sln^KK104306

sln^RNAi

(Nouri et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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