FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CASKUAS.cZa
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General Information
Symbol
Dmel\CASKUAS.cZa
Species
D. melanogaster
Name
FlyBase ID
FBal0260720
Feature type
allele
Associated gene
Dmel\CASK
Associated Insertion(s)
Carried in Construct
P{UAS-caki.Z}
Key Links
Transgenic product class
cDNA
(Zordan et al., 2005)
wild_type
(Zordan et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zordan et al., 2005)
wild_type
(Zordan et al., 2005)
Mutagen
in vitro construct
(Zordan et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-caki.Z}
Cytology
Description

UASt regulatory sequences drive expression of a 3.2kb CASK full-length cDNA with 474bp of upstream sequence and 1.016kb of downstream sequence.

(Zordan et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
CASK
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of CASKScer\UAS.cZa under the control of Scer\GAL4elav.PU rescues the locomotor activity and climbing defects of CRGΔ1877 flies.

      (Li et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/CASKUAS.cZa rescues CASKX-307/CASKX-313

      (Zordan et al., 2005)
      Fails to rescue

      Scer\GAL4elav-C155/CASKUAS.cZa fails to rescue CASKX-307/CASKX-313

      (Zordan et al., 2005)
      Comments

      Expression of CASKScer\UAS.cZa pan-neuronally under the control of Scer\GAL4elav-C155 fully rescues the neuromuscular junction miniature end-plate potential as well as the giant fiber habituation response defects found in CASKX-307/CASKX-313 mutant females but does not rescue any of these defects in male progeny.

      (Zordan et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CASKScer\UAS.cZa
      CASKUAS.cZa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)