FlyBase Allele Report: Dmel\rpr[87]

General Information

Symbol

Dmel\rpr⁸⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0260732

Feature type

allele

Associated gene

Dmel\rpr

Associated Insertion(s)

Carried in Construct

Also Known As

reaper⁸⁷

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Moon et al., 2008)

Progenitor genotype

P{SUPor-P}KG07184

(Moon et al., 2008)

Cytology

Description

A deletion extending 1860 bp 5' of the reaper transcript to 661 bp downstream resulting from the imprecise excision of P{SUPor-P}KG07184.

(Moon et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:18,396,892..18,400,263 [-]

Comment:

Estimated endpoints of deletion resulting from the imprecise excision of P{SUPor-P}KG07184, which is reported as extending from 1860 bp upstream to 661 bp downstream of the rpr transcript. Annotated transcription start site from R5.12 used for the mapping.

(Moon et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | oogenesis

(Park et al., 2019)

Phenotype Manifest In

germarium | oogenesis

(Park et al., 2019)

Detailed Description

Statement

Reference

Under normal conditions rpr⁸⁷ adults exhibit an increased cell death in germarium compared to controls. 6 hours after 3 Gy irradiation, they exhibit more cell death in germarium than untreated females, similar to controls.

(Park et al., 2019)

Homozygous animals do not show a defect in the programmed cell death of vCrz neurons: the neurons are no longer present at 7 hours after puparium formation, as occurs in wild-type.

(Lee et al., 2013)

As in wild type, rpr⁸⁷ mutant bursCCAP neurons undergo programmed cell death shortly after eclosion.

(Lee et al., 2013)

rpr⁸⁷ homozygotes do not show a significant increase in abdominal neuroblasts compared to wild-type.

rpr⁸⁷/Df(3L)X20 does not result in ectopic postembryonic neuroblasts.

(Tan et al., 2011)

Compared with wild-type, there is no appreciable change in the level of DNA-damaged induced apoptosis in homozygous rpr⁸⁷ mutant eye discs.

(Moon et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-enhancer of increased cell death phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

Suppressor of

Statement

Reference

rpr⁸⁷ is a suppressor of increased cell death | recessive phenotype of Rbf^120a

(Moon et al., 2008)

NOT Suppressor of

Statement

Reference

rpr⁸⁷/rpr⁸⁷ is a non-suppressor of increased cell death | third instar larval stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^CCAP.PP

(Lee et al., 2019)

rpr⁸⁷/rpr⁸⁷ is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^CCAP.PP

(Lee et al., 2019)

Df(3L)grim^C15E, rpr[+], rpr⁸⁷, + is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

rpr[+]/rpr⁸⁷ is a non-suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Df(3L)H99/rpr⁸⁷ is a non-suppressor of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PU, p53^GUS.PB

(Fan et al., 2010)

Other

Statement

Reference

Df(3L)grim^C15E, rpr⁸⁷ has abnormal neuroanatomy | recessive phenotype

(Tan et al., 2011)

Df(3L)grim^C15E/Df(3L)MM3, rpr⁸⁷ has abnormal neuroanatomy phenotype

(Tan et al., 2011)

Df(3L)grim^C15E/Df(3L)MM2, rpr⁸⁷ has abnormal neuroanatomy phenotype

(Tan et al., 2011)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-enhancer of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

Suppressor of

Statement

Reference

rpr⁸⁷ is a suppressor of eye disc phenotype of Rbf^120a

(Moon et al., 2008)

NOT Suppressor of

Statement

Reference

rpr⁸⁷/rpr⁸⁷ is a non-suppressor of larval CCAP neuron | third instar larval stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^CCAP.PP

(Lee et al., 2019)

Df(3L)grim^C15E, rpr[+], rpr⁸⁷, + is a non-suppressor of larval multidendritic class IV neuron | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

Df(3L)grim^C15E, rpr[+], rpr⁸⁷, + is a non-suppressor of dendrite | third instar larval stage phenotype of Scer\GAL4⁴⁷⁷, nanos^RNAi.UAS.WIZ

(Bhogal et al., 2016)

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-suppressor of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

rpr⁸⁷/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

rpr[+]/rpr⁸⁷ is a non-suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Df(3L)H99/rpr⁸⁷ is a non-suppressor of eye disc | posterior | third instar larval stage phenotype of Scer\GAL4^GMR.PU, p53^GUS.PB

(Fan et al., 2010)

Other

Statement

Reference

Df(3L)grim^C15E, rpr⁸⁷ has central nervous system phenotype

(Tan et al., 2011)

Df(3L)grim^C15E, rpr⁸⁷ has abdominal neuroblast phenotype

(Tan et al., 2011)

Df(3L)grim^C15E/Df(3L)MM3, rpr⁸⁷ has abdominal neuroblast phenotype

(Tan et al., 2011)

Df(3L)grim^C15E/Df(3L)MM2, rpr⁸⁷ has central nervous system phenotype

(Tan et al., 2011)

Df(3L)grim^C15E/Df(3L)MM2, rpr⁸⁷ has larval ventral nerve cord phenotype

(Tan et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The dendritic field coverage defects and loss of terminal branches observed in class IV dendritic arborizing neurons of third instar larvae expressing nos^{dsRNA.Scer\UAS.WIZ} under the control of Scer\GAL4⁴⁷⁷ is not suppressed by combination with single copies of both Df(3L)grim^C15E and rpr⁸⁷.

(Bhogal et al., 2016)

A rpr⁸⁷ mutant background does not affect the Scer\GAL4^GMR.PF>lin-52^GD12885 eye phenotype, and the number of dying cells remains unaltered.

(Bhaskar et al., 2014)

rpr⁸⁷, Df(3L)grim^C15E larvae display supernumerary ventral neuroblasts and abnormal central nervous system.

rpr⁸⁷, Df(3L)grim^C15E/Df(3L)MM3 larvae display supernumerary ventral neuroblasts.

The ventral nerve cord of one or two-day-old rpr⁸⁷, Df(3L)grim^C15E/Df(3L)MM2 adults is more than twice as wild-type. The abdominal segments extend far into the abdomen, unlike in the wild-type where they extend just to the caudal thorax. The thoracic segments of the central nervous system are also greatly expanded in the mutants.

(Tan et al., 2011)

A rpr⁸⁷/Df(3L)H99 background does not suppress the cell death seen when p53^GUS.PB is expressed in third instar eye discs under the control of Scer\GAL4^GMR.PU.

(Fan et al., 2010)

The level of DNA-damage induced cell death seen in Rbf^120a mutant eye discs is clearly reduced in the presence of rpr⁸⁷. rpr⁸⁷ does not affect the level or pattern of cell death in Rbf^120a mutant eye discs before irradiation treatment.

(Moon et al., 2008)

Xenogenetic Interactions

Statement

Reference

A rpr⁸⁷ heterozygous background does not rescue the reduced adult eye size found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev.

(Yang et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

83150

w^*; rpr⁸⁷/TM6B, Tb¹

600366

w^*; Df(3L)grim^C15E, PBac{WHr}grim^C15E rpr⁸⁷/TM3, P{GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

reaper⁸⁷

(Monteiro et al., 2023, Zhang et al., 2015)

rpr87

(Dichtel-Danjoy et al., 2013)

rpr⁸⁷

(Harding and White, 2019, Lee et al., 2019, Park et al., 2019, Xu et al., 2018, Bhogal et al., 2016, Beira et al., 2014, Bhaskar et al., 2014, Lee et al., 2013, Lee et al., 2013, Yang et al., 2013, Tan et al., 2011, Fan et al., 2010, Moon et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (16)

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