FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HiraHR1
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General Information
Symbol
Dmel\HiraHR1
Species
D. melanogaster
Name
FlyBase ID
FBal0262467
Feature type
allele
Associated gene
Dmel\Hira
Associated Insertion(s)
TI{TI}HiraHR1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Bonnefoy et al., 2007)
FLPase
(Bonnefoy et al., 2007)
I-SceI
(Bonnefoy et al., 2007)
Progenitor genotype
Associated Insertion(s)
TI{TI}HiraHR1
Cytology
Description

A 319bp fragment of the Hira gene (encompassing the entire predicted 5'UTR, the first exon, first intron and 5' part of the second exon) has been replaced by a w+mW.hs marker gene flanked with stop codons in all 6 reading frames.

(Bonnefoy et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Crosses of HiraHR1 mutant males free of Wolbachia infection to wild-type females free of Wolbachia infection result in significantly lower egg hatch rates (74.34 +/- 4.03%) relative to crosses of wild-type males free of Wolbachia infection to wild-type females free of Wolbachia infection. Early embryos derived from this cross show asynchronous nuclear divisions and chromatin bridges. The sex ratio ( female:male ) of the offspring is 0.62 +/- 0.05. Crosses of HiraHR1 mutant males free of Wolbachia infection to wild-type females infected with Wolbachia show no significant differences in hatch rate (89.38 +/- 8.06%) comparing with the uninfected crosses. The sex ratio ( female:male ) of the offspring is normal.

      (Zheng et al., 2011)

      Homozygous mutant females produce embryos that arrest just before hatching.

      The male pronucleus appears more condensed and smaller than the female pronucleus at the pronuclear apposition stage in eggs derived from mutant females. The male pronucleus remains abnormally small and condensed after pronuclear apposition and is unable to participate in the formation of the zygote.

      (Bonnefoy et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      HiraHR1 is a non-enhancer of partially lethal phenotype of Df(3R)3450/yem2

      (Orsi et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Hira185b

      (Bonnefoy et al., 2007)
      Rescued by

      HiraHR1 is rescued by Hira+tLa

      (Bonnefoy et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (6)