FlyBase Allele Report: Scer\GAL4[Hmgcr.B]

General Information

Symbol

Scer\GAL4^Hmgcr.B

Species

S. cerevisiae

Name

FlyBase ID

FBal0264325

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

Carried in Construct

P{Hmgcr.B-Gal4}

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Belgacem and Martin, 2007)

Progenitor genotype

Carried in construct

P{Hmgcr.B-Gal4}

Cytology

Description

A 10792bp fragment of Hmgcr putative promoter sequence (controlling expression of transcript B), corresponding to +2733bp to +13525bp (relative to the transcription start site) regulates expression of a GAL4 driver.

(Belgacem and Martin, 2007)

Allele components

Component

Use(s)

Regulatory region(s)

Hmgcr

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult corpus allatum

(Belgacem and Martin, 2007)

adult proventriculus

(Belgacem and Martin, 2007)

Additional Information

Statement

Reference

Marker for

Reflects expression of

Hmgcr

(Belgacem and Martin, 2007)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | larval stage, with Hmgcr^NIG.10367R

(Jones et al., 2010)

abnormal body size | adult stage, with Ac76E^UAS.Tag:HA

(Mattila et al., 2009)

abnormal body size | wandering third instar larval stage, with Ac76E^UAS.Tag:HA

(Mattila et al., 2009)

abnormal developmental rate, with Ac76E^UAS.Tag:HA

(Mattila et al., 2009)

abnormal developmental rate, with Hmgcr^NIG.10367R

(Jones et al., 2010)

abnormal locomotor rhythm, with Hmgcr^NIG.10367R

(Belgacem and Martin, 2007)

abnormal starvation stress response | female limited, with Ac76E^UAS.Tag:HA

(Mattila et al., 2009)

lethal | heat sensitive, with InR^NIG.18402R

(Belgacem and Martin, 2007)

partially lethal - majority die | first instar larval stage, with Hmgcr^NIG.10367R

(Jones et al., 2010)

partially lethal - majority die | second instar larval stage, with Hmgcr^NIG.10367R

(Jones et al., 2010)

partially lethal - majority die | third instar larval stage, with Hmgcr^NIG.10367R

(Jones et al., 2010)

Phenotype Manifest In

embryonic/larval tracheal dorsal trunk, with Hmgcr^NIG.10367R

(Jones et al., 2010)

larval tracheal system, with Hmgcr^NIG.10367R

(Jones et al., 2010)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^FRT.Act5C, Scer\GAL4^Hmgcr.B, Hmgcr^UAS.cvDa rescues Hmgcr⁰⁴⁶⁸⁴

(Belgacem and Martin, 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^Hmgcr.B

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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