FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\S6kUAS.cCa
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General Information
Symbol
Dmel\S6kUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Cheng
FlyBase ID
FBal0265716
Feature type
allele
Associated gene
Dmel\S6k
Associated Insertion(s)
Carried in Construct
P{UAS-S6k.C}
Key Links
Transgenic product class
wild_type
(Cheng et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Cheng et al., 2011)
Mutagen
in vitro construct
(Cheng et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-S6k.C}
Cytology
Description

UAS regulatory sequences drive expression of the S6k open reading frame.

(Cheng et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
S6k
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of S6kScer\UAS.cCa under the control of Scer\GAL4VGlut-OK371 has no effect on bouton size or number at the larval neuromuscular junction.

      (Cheng et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4VGlut1-OK371/S6kUAS.cCa is a non-suppressor of NMJ bouton | third instar larval stage phenotype of Pdk133

      (Cheng et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of S6kScer\UAS.cCa under the control of Scer\GAL4VGlut-OK371 does not rescue the reduction in bouton size at the neuromuscular junction which is seen in Pdk133 larvae.

      (Cheng et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/S6kUAS.cCa rescues Df(3L)CH18/S6kl-1

      (Cheng et al., 2011)

      Scer\GAL4VGlut1-OK371/S6kUAS.cCa rescues Df(3L)CH18/S6kl-1

      (Cheng et al., 2011)
      Fails to rescue

      S6kUAS.cCa/Scer\GAL4C57 fails to rescue Df(3L)CH18/S6kl-1

      (Cheng et al., 2011)
      Comments

      The decrease in bouton size which is seen at the neuromuscular junction in S6kl-1/Df(3L)CH18 third instar larvae is fully rescued by expression of S6kScer\UAS.cCa under the control of either Scer\GAL4elav-C155 or Scer\GAL4VGlut-OK371, but is not rescued by expression of S6kScer\UAS.cCa under the control of Scer\GAL4C57.

      Expression of S6kScer\UAS.cCa under the control of Scer\GAL4elav-C155 rescues the reduced active zone number and reduced reduced total synaptic area seen at the neuromuscular junction of S6kl-1/Df(3L)CH18 third instar larvae.

      (Cheng et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      S6kScer\UAS.cCa
      S6kUAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Cheng
      Secondary FlyBase IDs
        References (1)