FlyBase Allele Report: Dmel\dysc[UAS.long]

General Information

Symbol

Dmel\dysc^UAS.long

Species

D. melanogaster

Name

FlyBase ID

FBal0268519

Feature type

allele

Associated gene

Dmel\dysc

Associated Insertion(s)

Carried in Construct

P{UAS-dysc.long}

Also Known As

UAS-dysc

Key Links

Transgenic product class

cDNA

(Jepson et al., 2012)

wild_type

(Jepson et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Jepson et al., 2012)

wild_type

(Jepson et al., 2012)

Mutagen

in vitro construct

(Jepson et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-dysc.long}

Cytology

Description

UAS drives expression of a cDNA corresponding to a novel long isoform of dysc, designated isoform G.

(Jepson et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dysc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^elav.PU-mediated expression of dysc^Scer\UAS.g does not affect circadian rhythmicity.

(Jepson et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

dysc^UAS.long/Scer\GAL4^elav.PU rescues dysc^unspecified

(Jepson et al., 2014)

dysc^UAS.long/Scer\GAL4^elav.PU rescues dysc^c03838

(Jepson et al., 2014)

dysc^UAS.long/Scer\GAL4^elav.PU rescues dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^dysc.PJ rescues dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^C164 rescues dysc^s168/dysc^c03838

(Jepson et al., 2012)

Fails to rescue

dysc^UAS.long/Scer\GAL4^how-24B fails to rescue dysc^unspecified

(Jepson et al., 2014)

dysc^UAS.long/Scer\GAL4^P2.4.Pdf fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^tim.PE fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^ey-OK107 fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^Tab2-201Y fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^c819 fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^c107 fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^c061 fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^Ilp2.PR fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^dimm-929 fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^VGlut1-OK371 fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^how-24B fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

dysc^UAS.long/Scer\GAL4^repo.PU fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

Comments

Expression of dysc^{Scer\UAS.long} under the control of Scer\GAL4^elav.PU, but not under the control of Scer\GAL4^how-24B, rescues the reduction in bouton number and increase in bouton size at the neuromuscular junction which is seen in dysc^unspecified larvae.

The increase in evoked excitatory junctional current amplitude seen in dysc^c03838 larvae is rescued by expression of dysc^{Scer\UAS.long} under the control of Scer\GAL4^elav.PU.

(Jepson et al., 2014)

Scer\GAL4^elav.PU-, Scer\GAL4^dysc.PJ-, or Scer\GAL4^C164-mediated expression of dysc^Scer\UAS.g rescues the locomotor rhythm defects of dysc^c03838/dysc^s168 animals.

(Jepson et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dysc^Scer\UAS.g

dysc^{Scer\UAS.long}

dysc^UAS.long

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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