FB2026_02 , released June 18, 2026
Allele: Dmel\agoΔF.UAS
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General Information
Symbol
Dmel\agoΔF.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0268709
Feature type
allele
Associated gene
Dmel\ago
Associated Insertion(s)
Carried in Construct
P{UAS-ago.ΔF}
Also Known As
UAS-agoΔF
Key Links
Transgenic product class
inframe_deletion
(Mortimer and Moberg, 2007)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Mortimer and Moberg, 2007)
Mutagen
in vitro construct
(Mortimer and Moberg, 2007)
Progenitor genotype
Carried in construct
P{UAS-ago.ΔF}
Cytology
Description

UASt regulatory sequences drive expression of ago coding sequences lacking the core F-box domain.

(Mortimer and Moberg, 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ago
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of agoΔF.Scer\UAS under the control of Scer\GAL4hs.PB using heat shock results in an increase in terminal branching throughout the tracheal system.

      Expression of agoΔF.Scer\UAS under the control of Scer\GAL4tey-5053A approximately doubles the number of LF and LH tracheal branches that terminate on ventrolateral body wall muscle (VLM) 12 relative to either the adjacent muscle (VLM13) or to control larvae.

      (Mortimer and Moberg, 2013)

      Expression of agoΔF.Scer\UAS in the larval nervous system under the control of Scer\GAL4insc-Mz1407 does not affect neuroblast number.

      (Ouyang et al., 2011)

      Scer\GAL4btl.PS driven expression of agoΔF.Scer\UAS in the developing nervous system is sufficient to produce dorsal trunk breaks in approximately 39% of embryos.

      (Mortimer and Moberg, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Enhancer of
      Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in the number of tracheal branches that terminate on ventrolateral body wall muscle 12 caused by expression of agoΔF.Scer\UAS under the control of Scer\GAL4tey-5053A is suppressed if the flies are also heterozygous for either simaKG07607 or bnl00857.

      Co-expression of agoΔF.Scer\UAS and VhldsRNA.Scer\UAS.cMa under the control of Scer\GAL4tey-5053A results in a synergistic increase in the number of tracheal branches that terminate on ventrolateral body wall muscle (VLM) 12 compared to larvae expressing either agoΔF.Scer\UAS or VhldsRNA.Scer\UAS.cMa alone under the control of Scer\GAL4tey-5053A. In addition to increasing the branching of the LF and LH terminal cells onto VLM12 compared to each single mutant, the double mutants show recruitment of ectopic branches from the LG lateral terminal cell onto VLM12 in approximately 10% of cases.

      Co-expression of VhlScer\UAS.cAa partially suppresses the phenotype of an increased number of tracheal branches terminating on VLM12 caused by expression of agoΔF.Scer\UAS under the control of Scer\GAL4tey-5053A.

      (Mortimer and Moberg, 2013)

      Expression of agoΔF.Scer\UAS under the control of Scer\GAL4insc-Mz1407 reduces the number of ectopic neuroblasts by approximately 36% in a numb15 mutant background.

      Co-expression of agoΔF.Scer\UAS can partially suppress the neuroblast-loss phenotype induced by overexpression of p53Scer\UAS.Ex under the control of Scer\GAL4insc-Mz1407.

      (Ouyang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      agoΔF.Scer\UAS
      agoΔF.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (6)