FlyBase Allele Report: Dmel\NUCB1[NIG.32190R]

General Information

Symbol

Dmel\NUCB1^NIG.32190R

Species

D. melanogaster

Name

FlyBase ID

FBal0273688

Feature type

allele

Associated gene

Dmel\NUCB1

Associated Insertion(s)

Carried in Construct

P{NIG.32190R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.32190R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-32190R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage, with Scer\GAL4^αTub84B.PL

(Balasubramanian and Srinivasan, 2020)

majority die during P-stage, with Scer\GAL4^αTub84B.PL

(Balasubramanian and Srinivasan, 2020)

some die during larval stage, with Scer\GAL4^αTub84B.PL

(Balasubramanian and Srinivasan, 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing NUCB1^NIG.32190R under the control of Scer\GAL4^Ddc.PL do not show wing posture or flight defects.

Adults expressing NUCB1^NIG.32190R under the control of Scer\GAL4^NP3084 do not show significant changes in lifespan under a dead or live yeast diet, as compared to controls.

Adults expressing NUCB1^NIG.32190R under the control of Scer\GAL4^Toll-6-D42 do not show changes in climbing activity, as compared to controls.

(Balasubramanian and Srinivasan, 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor of visible | adult stage phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Orai[+], NUCB1^NIG.32190R, Orai^k11505, Scer\GAL4^Ddc.PL is a suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Scer\GAL4^Toll-6-D42, NUCB1^NIG.32190R/Itpr^90B.0 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Balasubramanian and Srinivasan, 2020)

Scer\GAL4^Toll-6-D42, NUCB1^NIG.32190R/Itpr^ug3 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Balasubramanian and Srinivasan, 2020)

NUCB1^NIG.32190R, Scer\GAL4^NP3084 is a suppressor | partially of short lived | nutrition conditional phenotype of Scer\GAL4^NP3084, norpA^KK105691

(Balasubramanian and Srinivasan, 2020)

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor of visible | adult stage phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Orai[+], NUCB1^NIG.32190R, Orai^k11505, Scer\GAL4^Ddc.PL is a suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NOT Suppressor of

Statement

Reference

NUCB1^NIG.32190R/Scer\GAL4^αTub84B.PL is a non-suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+], NUCB1^NIG.32190R, Scer\GAL4^Ddc.PL, SERCA^Kum170 is a non-suppressor of abnormal flight phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^NIG.32190R/Scer\GAL4^αTub84B.PL is a non-suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

SERCA[+], NUCB1^NIG.32190R, Scer\GAL4^Ddc.PL, SERCA^Kum170 is a non-suppressor of abnormal flight phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Scer\GAL4^Toll-6-D42, NUCB1^NIG.32190R/Itpr^ug3 is a non-suppressor of short lived phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Balasubramanian and Srinivasan, 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor of wing phenotype of Itpr^wc703/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

NUCB1^NIG.32190R/Scer\GAL4^Ddc.PL is a suppressor of wing phenotype of Itpr^wc361/Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

32190R-3

P{NIG.32190R}3

32190R-1

P{NIG.32190R}1/TM3, P{ActGFP}JMR2, Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

NUCB1^NIG.32190R

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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