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General Information
Symbol
Dmel\Hayan1
Species
D. melanogaster
Name
FlyBase ID
FBal0280357
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EP}HayanGS582 has resulted in a deletion that removes part of exon 5 and all of exon 6 of Hayan.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hayan1 mutant animals appear normal in terms of developmental rate and fertility.

When Hayan1 mutant flies are wounded during the adult stages, melanization is severely impaired around the wound site.

Hayan1 mutant flies subjected to severe wounding exhibit a reduced survival rate compared to controls. A similar reduction in survival is seen when flies are reared in germ-free conditions, indicating that the observed mortality is not due to infection. Wounding in the presence of bacteria did not further reduce the survival rate. The survival rate is improved when flies are exposed to a non-lethal concentration of a pro-oxidant (by ingesting paraquat). A similar increase in mortality is seen when wounding occurs at the larval stage.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Hayan1 has short lived | conditional phenotype, suppressible | partially by Jafrac1dsRNA.UAS/Scer\GAL4da.G32

Hayan1 has short lived | conditional phenotype, suppressible | partially by Jafrac1dsRNA.UAS/Scer\GAL4ChAT.7.4

Hayan1 has short lived | conditional phenotype, suppressible | partially by IrcdsRNA.UAS/Scer\GAL4da.G32

Hayan1 has short lived | conditional phenotype, suppressible | partially by IrcdsRNA.UAS/Scer\GAL4ChAT.7.4

Hayan1 has short lived | conditional phenotype, suppressible by pucE69/puc[+]

Hayan1 has partially lethal - majority die | larval stage | conditional phenotype, suppressible by pucE69/puc[+]

NOT suppressed by
Statement
Reference

Hayan1 has short lived | conditional phenotype, non-suppressible by Jafrac1dsRNA.UAS/Scer\GAL4He.PZ

Hayan1 has short lived | conditional phenotype, non-suppressible by IrcdsRNA.UAS/Scer\GAL4He.PZ

Suppressor of
Statement
Reference

Hayan1 is a suppressor of lethal | pupal stage phenotype of Spn28DcΔ2

Hayan1 is a suppressor of abnormal wound healing phenotype of Spn28DcΔ2

Phenotype Manifest In
Suppressor of
Statement
Reference

Hayan1 is a suppressor of trachea | larval stage phenotype of Spn28DcΔ2

Hayan1 is a suppressor of spiracle | larval stage phenotype of Spn28DcΔ2

Hayan1 is a suppressor of pupa phenotype of Spn28DcΔ2

Additional Comments
Genetic Interactions
Statement
Reference

A Hayan1 mutant background completely suppresses the spontaneous melanization seen when Spn27AdsRNA.Scer\UAS is expressed under the control of Scer\GAL4da.G32.

Hayan1 suppresses the exaggerated melanization seen in Spn28DcΔ2 mutant larvae following wounding. The spontaneous melanization seen in larval trachea and spiracles and lateral sides of the pupae are also abolished.

Hayan1 rescues the pupal stage lethality associated with Spn28DcΔ2 mutants.

A Hayan1 mutant background suppresses the spontaneous tracheal melanization seen when Spn77BadsRNA.WIZ.Scer\UAS is expressed under the control of Scer\GAL4da.G32.

Expression of Jafrac1dsRNA.Scer\UAS under the control of Scer\GAL4da.G32 partially suppresses the wound-induced mortality seen in Hayan1 mutants. The mortality is also rescued when Jafrac1dsRNA.Scer\UAS is expressed in neurons under the control of Scer\GAL4Cha.7.4, but not when it is expressed in hemocytes under the control of Scer\GAL4He.PZ.

Expression of IrcdsRNA.Scer\UAS under the control of Scer\GAL4da.G32 partially suppresses the wound-induced mortality seen in Hayan1 mutants. The mortality is also rescued when IrcdsRNA.Scer\UAS is expressed in neurons under the control of Scer\GAL4Cha.7.4, but not when it is expressed in hemocytes under the control of Scer\GAL4He.PZ.

A pucE69/+ mutant background suppresses the mortality induced when homozygous Hayan1 mutants are wounded at either the larval or adult stages.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of HayanScer\UAS.cNa under the control of Scer\GAL4He.PZ rescues the wound-induced mortality seen in Hayan1 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)