FlyBase Allele Report: Dmel\Dscam1[UAS.1.30.30.2]

General Information

Symbol

Dmel\Dscam1^{UAS.1.30.30.2}

Species

D. melanogaster

Name

FlyBase ID

FBal0284077

Feature type

allele

Associated gene

Dmel\Dscam1

Associated Insertion(s)

Carried in Construct

P{UAS-Dscam1.1.30.30.2.Z}

Key Links

Transgenic product class

wild_type

(Zhan et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zhan et al., 2004)

Mutagen

in vitro construct

(Andrews et al., 2008, Matthews et al., 2007, Zhu et al., 2006, Zhan et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-Dscam1.1.30.30.2.Z}

Cytology

Description

UAS regulatory sequences drive expression of a Dscam1 isoform which contains the alternative exons 4.1, 6.30, 9.30 and 17.2.

(Zhan et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Dscam1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Down syndrome

CEA with Dscam1^{ΔC.UAS.1.30.30.1.GFP}

(Hernández et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Down syndrome

modeled by Dscam1⁰⁵⁵¹⁸, fra⁴

(Hernández et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult mushroom body, with Scer\GAL4^elav-C155

(Zhan et al., 2004)

dendritic arborizing neuron, with Scer\GAL4^109(2)80

(Matthews et al., 2007)

embryonic/larval frontal nerve | embryonic stage, with Scer\GAL4^GMR10C11

(Hernández et al., 2023)

embryonic/larval frontal nerve | embryonic stage, with Scer\GAL4^GMR84B12

(Hernández et al., 2023)

embryonic/larval frontal nerve | embryonic stage, with Scer\GAL4^P2.4.Pdf

(Hernández et al., 2023)

embryonic/larval frontal nerve | embryonic stage, with Scer\GAL4^Ret.P2

(Hernández et al., 2023)

larval hindgut nerve | embryonic stage, with Scer\GAL4^GMR10C11

(Hernández et al., 2023)

larval hindgut nerve | embryonic stage, with Scer\GAL4^GMR84B12

(Hernández et al., 2023)

larval hindgut nerve | embryonic stage, with Scer\GAL4^P2.4.Pdf

(Hernández et al., 2023)

larval hindgut nerve | embryonic stage, with Scer\GAL4^Ret.P2

(Hernández et al., 2023)

lobe system of adult mushroom body, with Scer\GAL4^elav-C155

(Zhan et al., 2004)

Detailed Description

Statement

Reference

Expression of Dscam^{1.30.30.2.cAa.Scer\UAS} under the control of Scer\GAL4^ftz.ng results in ectopic axon crossing of the midline in embryos. The initial projection of the pCC axon is unaffected in these embryos.

Expression of Dscam^{1.30.30.2.cAa.Scer\UAS} under the control of Scer\GAL4^eve.RN2 has no effect on the pCC axon trajectory when assayed at stages 16/17.

(Andrews et al., 2008)

Larvae expressing Dscam^{1.30.30.2.cMa.Scer\UAS} in both the class I vpda neuron and the class III v'pda neuron under the control of Scer\GAL4^109(2)80 show very few overlaps between the two neurons (in contrast to wild type), with the two arbors segregating into nonoverlapping territories.

(Matthews et al., 2007)

Expression of Dscam^{1.30.30.2.Scer\UAS.cZa} under the control of Scer\GAL4^elav-C155 in large mushroom body clones in a wild-type background results in defects in the mushroom body, including disorganised lobes and ectopic projections of axons outside the mushroom body neuropil into adjacent brain regions.

(Zhan et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^scrt-11-6/Dscam1^{UAS.1.30.30.2} is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of Dscam1⁰⁵⁵¹⁸, fra⁴

(Hernández et al., 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^scrt-11-6/Dscam1^{UAS.1.30.30.2} is a suppressor of commissure | embryonic stage phenotype of Dscam1⁰⁵⁵¹⁸, fra⁴

(Hernández et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4²²¹/Dscam1^{UAS.1.30.30.2} partially rescues Dscam1²¹/Dscam1²³

(Matthews et al., 2007)

Scer\GAL4^elav-C155/Dscam1^{UAS.1.30.30.2} partially rescues Dscam1^unspecified

(Zhan et al., 2004)

Comments

The self-avoidance defects (dendrite crossings) seen in Dscam²¹/Dscam²³ class I da neurons are partially rescued by expression of Dscam^{1.30.30.2.cMa.Scer\UAS} under the control of Scer\GAL4²²¹.

(Matthews et al., 2007)

The branch segregation defects seen in homozygous Dscam^unspecified clones in the mushroom body are significantly rescued by expression of Dscam^{1.30.30.2.Scer\UAS.cZa} under the control of Scer\GAL4^elav-C155; 70 +/- 5% of the clones have wild-type morphology.

(Zhan et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Dscam1^{Scer\UAS.1.30.30.2}

Dscam1^{UAS.1.30.30.2}

Dscam^{1.30.30.2.Scer\UAS.cZa}

Dscam^{1.30.30.2.cAa.Scer\UAS}

Dscam^{1.30.30.2.cMa.Scer\UAS}

Dscam^{Scer\UAS.1.30.30.2}

Name Synonyms

Secondary FlyBase IDs

FBal0217461
FBal0217473
FBal0221312

References (6)

Report Sections

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