FlyBase Allele Report: Dmel\Hsp83[6-55]

General Information

Symbol

Dmel\Hsp83^6-55

Species

D. melanogaster

Name

FlyBase ID

FBal0291420

Feature type

allele

Associated gene

Dmel\Hsp83

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bandura et al., 2013)

Mutagen

ethyl methanesulfonate

(Bandura et al., 2013)

Progenitor genotype

Cytology

Description

Amino acid replacement: P380S.

(Bandura et al., 2013)

Contains a C to T change at 3L coordinate 3195636 (release 5.8), resulting in a proline to serine change at residue 380 in the Hsp83 protein.

(Bandura et al., 2013)

Nucleotide substitution: C3195636T.

(Bandura et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:3,195,636..3,195,636 [+]

Nucleotide change:

C3195636T

Amino acid change:

P380S | Hsp83-PA; P380S | Hsp83-PB

Reported amino acid change:

P380S

(Bandura et al., 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | pupal stage | somatic clone

(Bandura et al., 2013)

increased occurrence of cell division | somatic clone | third instar larval stage

(Bandura et al., 2013)

lethal (with Hsp83^j5C2)

(Bandura et al., 2013)

lethal (with Hsp83^P582)

(Bandura et al., 2013)

lethal - all die before end of pupal stage

(Bandura et al., 2013)

male sterile (with Hsp83^e1D)

(Bandura et al., 2013)

male sterile (with Hsp83^e3A)

(Bandura et al., 2013)

male sterile (with Hsp83^e4A)

(Bandura et al., 2013)

male sterile (with Hsp83^e6A)

(Bandura et al., 2013)

male sterile (with Hsp83^e6D)

(Bandura et al., 2013)

partially lethal (with Hsp83^13F3)

(Bandura et al., 2013)

partially lethal (with Hsp83^19F2)

(Bandura et al., 2013)

Phenotype Manifest In

eye disc | somatic clone | third instar larval stage

(Bandura et al., 2013)

Detailed Description

Statement

Reference

The cells in Hsp83^6-55 mutant clones experience a delay in cell cycle exit.

Hsp83^6-55 mutant clones in the proliferating regions of third instar larval eye or wing discs contain a similar number of mitotic cells as controls. Occasional mitotic cells are observed in the non-proliferating regions of the eye disc posterior to the morphogenetic furrow. Clone cells from the eye have a cell cycle that appears the same as in controls, although in wings more cells are in G2 than in controls.

(Bandura et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions