FB2026_02 , released June 18, 2026
Allele: Dmel\Fer2UAS.Tag:FLAG
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General Information
Symbol
Dmel\Fer2UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0299743
Feature type
allele
Associated gene
Dmel\Fer2
Associated Insertion(s)
Carried in Construct
P{UAS-Fer2-FLAG}
Key Links
Transgenic product class
cDNA
(Bou Dib et al., 2014)
wild_type
(Bou Dib et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Bou Dib et al., 2014)
wild_type
(Bou Dib et al., 2014)
Mutagen
in vitro construct
(Bou Dib et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Fer2-FLAG}
Cytology
Description

UAS regulatory sequences drive expression of Fer2 cDNA tagged at the C-terminal end with 3xTag:FLAG.

(Bou Dib et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Fer2
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by foxoΔ94
      (Tas et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of Fer2UAS.Tag:FLAG under the control of either or Scer\GAL4GMR58E02 or Scer\GAL4Fer2.2359 suppresses the progressive decrease in the number of adult PAM neurons observed in foxoΔ94 homozygotes. The expression of Fer2UAS.Tag:FLAG under the control of Scer\GAL4GMR58E02 also partially suppresses the decreased lifespan and adult locomotion presented by foxoΔ94 homozygotes.

      (Tas et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Fer2UAS.Tag:FLAG/Scer\GAL4Fer2.2359 rescues Fer2MB09480

      (Bou Dib et al., 2014)
      Partially rescues

      Fer2UAS.Tag:FLAG/Scer\GAL4Fer2.2359 partially rescues Fer2e03248

      (Bou Dib et al., 2014)

      Fer2UAS.Tag:FLAG/Scer\GAL4GMR58E02 partially rescues Fer2MB09480

      (Bou Dib et al., 2014)
      Fails to rescue

      Fer2UAS.Tag:FLAG/Scer\GAL4GMR58E02 fails to rescue Fer2e03248

      (Bou Dib et al., 2014)

      Scer\GAL4Ddc.HL9/Fer2UAS.Tag:FLAG fails to rescue Fer2e03248

      (Bou Dib et al., 2014)
      Comments

      Expression of Fer2Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Fer2.2359 partially but significantly rescues the climbing defects seen in Fer2e03248 mutant flies. The PAM and PAL dopaminergic neuron loss is also rescued to quasi wild-type levels.

      Expression of Fer2Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Fer2.2359 fully rescues the climbing defects seen in Fer2MB09480 mutant flies. The PAM dopaminergic loss is also rescued.

      Expression of Fer2Scer\UAS.T:Zzzz\FLAG in PAM neurons under the control of either Scer\GAL4GMR58E02 or Scer\GAL4Ddc.HL9 does not rescue the PAM neuron loss in Fer2e03248 mutant flies.

      Expression of Fer2Scer\UAS.T:Zzzz\FLAG in PAM neurons under the control of either Scer\GAL4GMR58E02 partially rescues the PAM neuron loss in Fer2MB09480 mutant flies. The climbing defects are also partially rescued.

      (Bou Dib et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fer2Scer\UAS.T:Zzzz\FLAG
      Fer2UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)