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General Information
Symbol
Dmel\aurB2A43
Species
D. melanogaster
Name
FlyBase ID
FBal0301281
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Estimated coordinates of a 19 bp deletion that causes a frameshift at amino acid 213 and early translation termination.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

aurB2A43 mutants exhibit a frame shift followed by a truncation in the kinase activation loop.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

aurB2A43 mutant germline clones exhibit defects in early germ-cell development, with the formation of a giant germline stem cell that fills the entire germarium. These mutant cells display highly polyploid nuclei, enlarged spectrosomes and do not come out of the germarium.

aurB2A43 mutants display highly polyploidy cells and early arrest of oogenesis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The fraction of egg chambers containing 32 cells and the fraction of germaria containing 'stem cysts' in which the female germline stem cells are interconnected to daughter cells is reduced in aurB2A43/shrbG5 double heterozygotes compared to shrbG5 heterozygotes.

A aurB2A43/+ background partially rescues the extra germline cells phenotype found in females expressing DetS125E.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)