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General Information
Symbol
Dmel\shrbG5
Species
D. melanogaster
Name
FlyBase ID
FBal0230153
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
vps32G5
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

384 bp deletion

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

shrbG5 contains a 384bp deletion.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

70% of heterozygous female germaria contain 'stem cysts' in which the female germline stem cells (GSCs) are interconnected to several daughter cells (both linear and branched chains of cells are seen).

54% of egg chambers have 32 cells in shrbG5/+ females. 55% of heterozygous germaria contain 'stem cysts' in which the female germline stem cells are interconnected to daughter cells. The cells in these stem cysts share the same cytoplasm.

shrbG5 mutant clones in late third instar larval eye imaginal discs causes non-autonomous overproliferation of neighbouring wild type cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

shrbG5 has cytokinesis defective | dominant phenotype, enhanceable by l(2)gd1[+]/l(2)gd1d7

Suppressed by
Statement
Reference

shrbG5 has cytokinesis defective | dominant phenotype, suppressible by aurB35.33/aurB[+]

shrbG5 has cytokinesis defective | dominant phenotype, suppressible by aurB2A43/aurB[+]

Phenotype Manifest In
Enhanced by
Statement
Reference

shrbG5 has female germline stem cell phenotype, enhanceable by l(2)gd1[+]/l(2)gd1d7

Suppressed by
Statement
Reference

shrbG5 has egg chamber phenotype, suppressible by aurB2A43/aurB[+]

shrbG5 has female germline cell phenotype, suppressible by aurB2A43/aurB[+]

shrbG5 has female germline stem cell phenotype, suppressible by aurB2A43/aurB[+]

shrbG5 has egg chamber phenotype, suppressible by l(2)gd1[+]/l(2)gd1d7

shrbG5 has female germline cell phenotype, suppressible by l(2)gd1[+]/l(2)gd1d7

shrbG5 has egg chamber phenotype, suppressible by aurB35.33/aurB[+]

shrbG5 has female germline cell phenotype, suppressible by aurB35.33/aurB[+]

shrbG5 has female germline stem cell phenotype, suppressible by aurB35.33/aurB[+]

Enhancer of
Statement
Reference

shrbG5/shrb[+] is an enhancer of eye photoreceptor cell phenotype of Hsap\HTTGMR.Q120

Suppressor of
Statement
Reference

shrbG5 is a suppressor | partially of wing vein L5 phenotype of rhove-1

shrbG5 is a suppressor of wing vein L5 phenotype of Df(3L)ru-22/rhove-1

Additional Comments
Genetic Interactions
Statement
Reference

The fraction of egg chambers containing 32 cells is reduced in l(2)gd1d7/shrbG5 double heterozygotes compared to shrbG5 heterozygotes. The fraction of germaria containing 'stem cysts' in which the female germline stem cells are interconnected to daughter cells is increased in l(2)gd1d7/shrbG5 double heterozygotes compared to shrbG5 heterozygotes.

The fraction of egg chambers containing 32 cells and the fraction of germaria containing 'stem cysts' in which the female germline stem cells are interconnected to daughter cells is reduced in aurB2A43/shrbG5 double heterozygotes compared to shrbG5 heterozygotes.

The fraction of egg chambers containing 32 cells and the fraction of germaria containing 'stem cysts' in which the female germline stem cells are interconnected to daughter cells is reduced in aurB35.33/shrbG5 double heterozygotes compared to shrbG5 heterozygotes.

Atg61 suppresses the non-autonomous overgrowth seen in shrbG5 mutant eye disc clones.

A shrbG5 heterozygous background leads to almost full suppression of the L5 wing vein defect in rhove-1/Df(3L)ru-22 kst1 mutants and 80% suppression in rhove-1/rhove-1 kst1 flies.

Xenogenetic Interactions
Statement
Reference

The loss of photoreceptors that is seen in flies expressing Hsap\HDGMR.Q120 is enhanced if the flies also carry one copy of shrbG5.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)