FlyBase Allele Report: Dmel\drl[UAS.cYa]

General Information

Symbol

Dmel\drl^UAS.cYa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Yao

FlyBase ID

FBal0301390

Feature type

allele

Associated gene

Dmel\drl

Associated Insertion(s)

Carried in Construct

P{UAS-drl.Y}

Also Known As

UAS-drl

Key Links

Transgenic product class

cDNA

(Yao et al., 2007)

wild_type

(Yao et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Yao et al., 2007)

wild_type

(Yao et al., 2007)

Mutagen

in vitro construct

(Yao et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-drl.Y}

Cytology

Description

UASt regulatory sequences drive expression of a full-length drl cDNA.

(Yao et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

drl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^GH146

(Wu et al., 2014)

Phenotype Manifest In

adult antennal lobe projection neuron VA4 lPN, with Scer\GAL4^GH146

(Wu et al., 2014)

adult antennal lobe projection neuron VC2 lPN, with Scer\GAL4^GH146

(Wu et al., 2014)

adult antennal lobe projection neuron VM1 lPN, with Scer\GAL4^GH146

(Wu et al., 2014)

adult antennal lobe projection neuron VM3 adPN, with Scer\GAL4^GH146

(Wu et al., 2014)

dendrite | adult stage, with Scer\GAL4^GH146

(Wu et al., 2014)

Detailed Description

Statement

Reference

Expression of drl^Scer\UAS.cYa under the control of Scer\GAL4^GH146 results in dendrite targeting defects in the ventromedial domain of the adult antennal lobe. The VM1 dendrites are absent, while the VA4, VC2 and VM3 dendrites are often displaced more anteriorly than normal.

(Wu et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^GH146/drl^UAS.cYa is a suppressor of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^GH146, Wnt5^UAS.cFa

(Wu et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^GH146/drl^UAS.cYa is a suppressor of adult antennal lobe phenotype of Scer\GAL4^GH146, Wnt5^UAS.cFa

(Wu et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of drl^Scer\UAS.cYa suppresses the distortion of the antennal lobe caused by expression of Wnt5^Scer\UAS.cFa under the control of Scer\GAL4^GH146.

(Wu et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^GH146/drl^UAS.cYa partially rescues drl²

(Yao et al., 2007)

Scer\GAL4^repo.PU/drl^UAS.cYa partially rescues drl²

(Yao et al., 2007)

Fails to rescue

Scer\GAL4^elav.PU/drl^UAS.cYa fails to rescue drl²

(Yao et al., 2007)

Comments

Expression of drl^Scer\UAS.cYa in homozygous drl^unspecified MARCM projection neuron clones induced in a drl^unspecified/+ background substantially rescues the dendrite targeting defects of these clones, although some gain of function phenotypes are also seen.

(Wu et al., 2014)

Expression of drl^Scer\UAS.cYa under the control of Scer\GAL4^GH146 partially rescues the antennal lobe defects of drl² adults: glomerular defects remain but protrusions from the antennal lobe are absent.

Expression of drl^Scer\UAS.cYa under the control of Scer\GAL4^repo.PU strongly rescues the antennal lobe defects of drl² adults: the midline defects are completely rescued and the occurrence of targeting defects is strongly reduced.

Expression of drl^Scer\UAS.cYa under the control of Scer\GAL4^elav.PU does not rescue the antennal lobe defects of drl² adults.

(Yao et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

drl^Scer\UAS.cYa

drl^UAS.cYa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Yao

Secondary FlyBase IDs

References (2)

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